Clinical and Laboratory Characteristics of Pandemic Influenza A/H1N1 2009 Infection among Patients with Malignancy in Korea

Hyeon Jeong Goong; Yu Ri Seo; La Young Yoon; Soon Ha Kwon; Eun Jung Lee; Min Hyok Jeon; Tae Hyong Kim; Dae Sik Hong; Eun Ju Choo

doi:10.3947/ic.2012.44.1.1

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Goong, Seo, Yoon, Kwon, Lee, Jeon, Kim, Hong, and Choo: Clinical and Laboratory Characteristics of Pandemic Influenza A/H1N1 2009 Infection among Patients with Malignancy in Korea

Original Article

Infection & Chemotherapy

Infection & Chemotherapy 2012; 44(1): 1-4.

Published online: 29 February 2012

DOI: https://doi.org/10.3947/ic.2012.44.1.1

Clinical and Laboratory Characteristics of Pandemic Influenza A/H1N1 2009 Infection among Patients with Malignancy in Korea

Hyeon Jeong Goong, Yu Ri Seo, La Young Yoon, Soon Ha Kwon, Eun Jung Lee, Min Hyok Jeon, Tae Hyong Kim, Dae Sik Hong, Eun Ju Choo

Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, Korea.

Correspondence to Eun Ju Choo, M.D. Department of Internal Medicine, Soonchunhyang University College of Medicine, 1174 Jung-dong, Wonmi-gu, Bucheon 420-767, Korea. Tel: +82-32-621-5202, Fax: +82-32-621-5018, mdchoo@schmc.ac.kr

Received 20 June 2011 Revised 8 January 2012 Accepted 16 January 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Patients with malignancy are considered to be at high risk of severe pandemic influenza A/H1N1 2009. This study was conducted to identify the severity of pandemic influenza A/H1N1 2009 among patients with malignancy.

Materials and Methods

Between August 2009 and December 2009, we reviewed clinical data and medical records of 31 patients with malignancy and 63 hospitalized patients without malignancy.

Results

Eighty-three patients with laboratory-confirmed pandemic influenza A/H1N1 2009 were admitted. The rate of ICU admission was higher among patients with malignancy (without malignancy 13% vs with malignancy 35%, P=0.024). The mortality rate was higher among patients with malignancy (without malignancy 6% vs with malignancy 25%, P=0.033). Patients using immunosuppressants showed a higher rate of lower respiratory tract infection (83% vs 24%, P=0.013).

Conclusions

Pandemic influenza A/H1N1 2009 in patients with malignancy was more severe than in patients without malignancy.

Keywords: Pandemic influenza A/H1N1 2009, Malignancy

Figures and Tables

Table 1

Clinical Characteristics of Patients with Malignancy Who Were Confirmed to be Infected with Pandemic Influenza A/H1N1 2009

Table 2

Clinical and Laboratory Characteristics of 83 Patients with Laboratory-confirmed Pandemic Influenza A/H1N1 2009: Comparison between Subjects with Malignancy and without Malignancy

LRTI, Lower respiratory tract infection; ICU, Intensive care unit.

Table 3

Clinical Characteristics of 31 Patients with Malignancy with Pandemic Influenza A/H1N1 2009: Comparison between Lower and Upper Respiratory Tract Infection

LRTI, lower respiratory tract infection; URTI, Upper respiratory tract infection.

^aChronic cardiovascular disease, Chronic renal disease, Chronic liver disease, Chronic respiratory disease, Diabetes mellitus.

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ORCID iDs: Tae Hyong Kim
https://orcid.org/http://orcid.org/0000-0003-2920-9038
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