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Jae-Ki Choi, Jin-Hee No, Bo-Hee Lee, Jae-Seung Yun, Si-Hyun Kim, Jae-Cheol Kwon, Ji-Hyung Hong, Guk-Jin Lee, Sun Hee Park, Su-Mi Choi, Dong-Gun Lee
, Jung-Hyun Choi, Jin-Hong Yoo
, Jung-Hyun Choi, Jin-Hong Yoo
Abstract
Invasive tracheobronchial aspergillosis (iTBA) is an uncommon clinical manifestation of invasive aspergillosis and this is usually limited to the large airways. Its pathophysiology and clinical features are obscure, but some fatal cases of iTBA in immunocompetent patients have also been reported. We describe 4 cases of iTBA in the patients with hematologic malignancies, that was early diagnosed by bronchoscopy, a computed tomography and successfully treated by proper antifungal treatment. And we also review the cases of iTBA reported in Korea.
Figures and Tables
Figure 2
CT scan of the chest. Figure 2A shows nodular thickening and enhancement of the anterior tracheal wall (case 2) and figure 2B shows peripheral rim enhancement and luminal narrowing of the right main bronchus and the right upper bronchus (case 3).
Table 1
Summary of the Cases of Invasive Tracheobronchial Aspergillosis Reported in Korea
ALL, acute lymphoblastic leukemia; AMB, amphotericin B deoxycholate; AML, acute myeloid leukemia; ANC, absolute neutrophil count; CR, complete response; DM, diabetes mellitus; GM, galactomannan; IPA, invasive pulmonary aspergillosis; KT, kidney transplantation; MDS, myelodysplastic syndrome; NM, not mentioned; PMTBA, pseudomembranous tracheobronchitis; TBA, Tracheobronchial aspergillosis; UTBA, ulcerative tracheobronchitis; WBC, white blood cells
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