Journal List > Infect Chemother > v.43(1) > 1035131

Kim, Shin, Kim, Cho, Lee, Kim, Jeon, Park, Kim, Lee, and Park: Testicular Tuberculosis That Mimicked Testicular Cancer


Next to lymphatic involvement, genitourinary tuberculosis is considered the second most common manifestation of extrapulmonary tuberculosis worldwide. However, testicular and spermatic cord involvement is uncommon. We report here on a case of testicular and spermatic cord tuberculosis that masqueraded as testicular cancer. A 25-year-old man was admitted to our hospital with painless right scrotal swelling for past 2 months. The abdominal CT scan showed a heterogenous testicular mass that was suspicious for being malignancy. He underwent right radical orchiectomy; testicular and spermatic cord tuberculosis was revealed on histopathological examination. This case highlights the importance of taking a thoughtful diagnostic approach for testicular and spermatic cord tuberculosis, including fine needle aspiration before performing surgical exploration.

Figures and Tables

Figure 1
On the ultrasonographic images, the right testis shows enlargement and inhomogeneous echogenecity. On the color Doppler images, the right testis shows increased vascularity (A). The enhanced CT scan reveals an enlarged right testis, which demonstrated inhomogenous density and necrotic foci (B).
Figure 2
The chest radiograph shows fibrocalcified nodules in both upper lobes (A). The chest CT reveals centrilobular nodules and a tree-in bud pattern in both upper lobes (B).
Figure 3
Pathologic examination demonstrats normal testicular tissue on the left lower corner, while with necrotizing granulomas and Langerhans cells (arrows) on the center (H&E stain, ×100).


1. Jacob JT, Nguyen TM, Ray SM. Male genital tuberculosis. Lancet Infect Dis. 2008. 8:335–342.
2. Biswas M, Rahi R, Tiwary SK, Khanna R, Khanna AK. Isolated tuberculosis of testis. Kathmandu Univ Med J (KUMJ). 2006. 4:98–99.
3. Korea Center for Disease Control and Prevention, Korean Institute of Tuberculosis. Annual report on the notified tuberculosis patients in Korea. 2008. Seoul: Korea Center for Disease Control and Prevention, Korean Institute of Tuberculosis.
4. Kulchavenya E, Khomyakov V. Male genital tuberculosis in Siberians. World J Urol. 2006. 24:74–78.
5. Gokce G, Kilicarslan H, Ayan S, Tas F, Akar R, Kaya K, Gultekin EY. Genitourinary tuberculosis: a review of 174 cases. Scand J Infect Dis. 2002. 34:338–340.
6. Lee Y, Huang W, Huang J, Wang J, Yu C, Jiaan B, Huang J. Efficacy of chemotherapy for prostatic tuberculosis-a clinical and histologic follow-up study. Urology. 2001. 57:872–877.
7. Moussa OM, Eraky I, El-Far MA, Osman HG, Ghoneim MA. Rapid diagnosis of genitourinary tuberculosis by polymerase chain reaction and non-radioactive DNA hybridization. J Urol. 2000. 164:584–588.
8. Hemal AK, Gupta NP, Rajeev TP, Kumar R, Dar L, Seth P. Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture. Urology. 2000. 56:570–574.
9. Torrea G, Van de Perre P, Ouedraogo M, Zougba A, Sawadogo A, Dingtoumda B, Diallo B, Defer MC, Sombié I, Zanetti S, Sechi LA. PCR-based detection of the Mycobacterium tuberculosis complex in urine of HIV-infected and uninfected pulmonary and extrapulmonary tuberculosis patients in Burkina Faso. J Med Microbiol. 2005. 54:39–44.
10. Wang LJ, Wong YC, Chen CJ, Lim KE. CT features of genitourinary tuberculosis. J Comput Assist Tomogr. 1997. 21:254–258.
11. Doherty FJ. Ultrasound of the nonacute scrotum. Semin Ultrasound CT MR. 1991. 12:131–156.
12. Cassidy FH, Ishioka KM, McMahon CJ, Chu P, Sakamoto K, Lee KS, Aganovic L. MR imaging of scrotal tumors and pseudotumors. Radiographics. 2010. 30:665–683.
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