Journal List > Infect Chemother > v.43(6) > 1035118

Song: Antimicrobial Resistance in Gram-positive Cocci: Past 50 Years, Present and Future

Abstract

Widespread development of antimicrobial resistance by major bacterial pathogens including Staphylococcus aureus, Streptococcus pneumoniae, Enterococci, and gram-negative bacilli have emerged as a global healthcare concern. Antimicrobial resistance was first identified during the 1940s and 50s with penicillin resistance in S. aureus. During the 1970s and 80s, methicillin-resistant S. aureus (MRSA) rapidly emerged as a major nosocomial pathogen in hospitals throughout the world. In the 1990s, a variation of MRSA emerged as community-associated MRSA (CA-MRSA), which is contracted outside of the hospital setting, and has become one of the most common pathogens associated with skin and skin structure infections in the United States and other parts of the world. Vancomycin-intermediate S. aureus (VISA) was first reported in 1996, and high-level vancomycin-resistant S. aureus (VRSA) was reported in 2002. S. pneumoniae has demonstrated a significant increase in resistance to macrolides and beta-lactam agents since 1980s, particularly in Asian countries while penicillin resistance is not prevalent among non-meningeal isolates according to the new breakpoints from CLSI. Vancomycin resistant enterococci, particularly E. faecium, is a major concern associated with nosocomial infections in many hospitals. Given the widespread emergence and spread of antimicrobial resistant gram-positive cocci during recent decades, the problem is likely to continue to increase as a critical, clinical problem.

Figures and Tables

Table 1
History of Antimicrobial Agents and Emerging Resistance (1940-2010)
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Table 2
Criteria for Glycopeptides Resistance in S. aureus
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CLSI, Clinical Laboratory and Standards Institute; EUCAST, European Committee on Antimicrobial Susceptibility Testing; VSSA, Vancomycin susceptible S. aureus; VISA, Vancomycin-intermediate S. aureus; VRSA, Vancomycin resistant S. aureus

References

1. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009. 48:1–12.
crossref
2. Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother. 1997. 40:135–136.
crossref
3. Centers for Disease Control and Prevention (CDC). Staphylococcus aureus resistant to vancomycin--United States, 2002. MMWR Morb Mortal Wkly Rep. 2002. 51:565–567.
4. Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet. 2006. 368:874–885.
crossref
5. Deurenberg RH, Stobberingh EE. The evolution of Staphylococcus aureus. Infect Genet Evol. 2008. 8:747–763.
6. Ko KS, Lee JY, Suh JY, Oh WS, Peck KR, Lee NY, Song JH. Distribution of major genotypes among methicillin-resistant Staphylococcus aureus clones in Asian countries. J Clin Microbiol. 2005. 43:421–426.
crossref
7. Kim JM, Park ES, Jeong JS, Kim KM, Kim JM, Oh HS, Yoon SW, Chang HS, Chang KH, Lee SI, Lee MS, Song JH, Kang MW, Park SC, Choe KW, Pai CH. Nosocomial Infection Surveillance Committee of the Korean Society for Nosocomial Infection Control. Multicenter surveillance study for nosocomial infections in major hospitals in Korea. Am J Infect Control. 2000. 28:454–458.
crossref
8. Chong Y, Lee K, Park YJ, Jeon DS, Lee MH, Kim MY, Chang CH, Kim EC, Lee NY, Kim HS, Kang ES, Cho HC, Paik IK, Lee HS, Jang SJ, Park AJ, Cha YJ, Kang SH, Lee MH, Song W, Shin JH. Korean nationwide surveillance of antimicrobial resistance of bacteria in 1997. Yonsei Med J. 1998. 39:569–577.
crossref
9. Lee K, Chang CL, Lee NY, Kim HS, Hong KS, Cho HC. Korean nationwide surveillance of antimicrobial resistance of bacteria in 1998. Yonsei Med J. 2000. 41:497–506.
crossref
10. Kim HB, Jang HC, Nam HJ, Lee YS, Kim BS, Park WB, Lee KD, Choi YJ, Park SW, Oh MD, Kim EC, Choe KW. In vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiary-care hospitals in Korea: a nationwide survey. Antimicrob Agents Chemother. 2004. 48:1124–1127.
crossref
11. Hong SG, Yong D, Lee K, Kim EC, Lee WK, Jeong SH, Song WK, Park YJ, Kim MN, Uh Y, Shin JH, Lee J, Ahn JY, Lee SW, Kim JS, Shin HB. Antimicrobial resistance of clinically important bacteria isolated from hospitals located in representative provinces of Korea. Korean J Clin Microbiol. 2003. 6:29–36.
12. Hong SG, Lee J, Yong D, Kim EC, Jeong SH, Park YJ, Choi TY, Uh Y, Shin JH, Lee WK, Ahn JY, Lee SH, Woo GJ, Lee K. Antimicrobial resistance of clinically important bacteria isolated from 12 hospitals in Korea. Korean J Clin Microbiol. 2004. 7:171–177.
13. Lee H, Yong D, Lee K, Hong SG, Kim EC, Jeong SH, Park YJ, Choi TY, Uh Y, Shin JH, Lee WK, Lee J, Ahn JY, Lee SH, Woo GJ. Antimicrobial resistance of clinically important bacteria isolated from 12 hospitals in Korea in 2004. Korean J Clin Microbiol. 2005. 8:66–73.
14. Lee H, Kim CK, Lee J, Lee SH, Ahn JY, Hong SG, Park YJ, Jeong SH, Kim EC, Lee WK, Uh Y, Shin JH, Choi TY, Kwak HS, Lee K. Antimicrobial resistance of clinically important bacteria isolated from 12 hospitals in Korea in 2005 and 2006. Korean J Clin Microbiol. 2007. 10:59–69.
15. Salgado CD, Farr BM, Calfee DP. Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis. 2003. 36:131–139.
crossref
16. Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, Carey RB, Talan DA. EMERGEncy ID Net Study Group. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006. 355:666–674.
crossref
17. Liu C, Graber CJ, Karr M, Diep BA, Basuino L, Schwartz BS, Enright MC, O'Hanlon SJ, Thomas JC, Perdreau-Remington F, Gordon S, Gunthorpe H, Jacobs R, Jensen P, Leoung G, Rumack JS, Chambers HF. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008. 46:1637–1646.
crossref
18. Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, Etienne J, Johnson SK, Vandenesch F, Fridkin S, O'Boyle C, Danila RN, Lynfield R. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003. 290:2976–2984.
crossref
19. Song JH, Hsueh PR, Chung DR, Ko KS, Kang CI, Peck KR, Yeom JS, Kim SW, Chang HH, Kim YS, Jung SI, Son JS, So TM, Lalitha MK, Yang Y, Huang SG, Wang H, Lu Q, Carlos CC, Perera JA, Chiu CH, Liu JW, Chongthaleong A, Thamlikitkul V, Van PH. ANSORP Study Group. Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother. 2011. 66:1061–1069.
crossref
20. Kim HB, Shin DH, Park KU, Oh MD, Kim EC, Choe KW. The methicillin-resistance rate of Staphylococcus aureus isolatd from anterior nares of healthy adults in the community. Korean J Infect Dis. 1998. 30:527–531.
21. Kim ES, Song JS, Lee HJ, Choe PG, Park KH, Cho JH, Park WB, Kim SH, Bang JH, Kim DM, Park KU, Shin S, Lee MS, Choi HJ, Kim NJ, Kim EC, Oh MD, Kim HB, Choe KW. A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea. J Antimicrob Chemother. 2007. 60:1108–1114.
crossref
22. Mun HM, Kim SD, Chun B, Lee S, Kim MN, Sim JJ, Choi HR, Park HJ, Han MK, Kwak SH, Hong MJ, Woo JH. Community and hospital onset methicillin-resistant Staphylococcus aureus in a tertiary care teaching hospital. Korean J Nosocomial Infect Control. 2009. 14:24–35.
23. Chung G, Cha J, Han S, Jang H, Lee K, Yoo J, Yoo J, Kim H, Eun S, Kim B, Park O, Lee Y. Nationwide surveillance study of vancomycin intermediate Staphylococcus aureus strains in Korean hospitals from 2001 to 2006. J Microbiol Biotechnol. 2010. 20:637–642.
24. Howden BP, Davies JK, Johnson PD, Stinear TP, Grayson ML. Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev. 2010. 23:99–139.
crossref
25. Périchon B, Courvalin P. VanA-type vancomycin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009. 53:4580–4587.
26. Tiwari HK, Sen MR. Emergence of vancomycin resistant Staphylococcus aureus (VRSA) from a tertiary care hospital from northern part of India. BMC Infect Dis. 2006. 6:156.
27. Aligholi M, Emaneini M, Jabalameli F, Shahsavan S, Dabiri H, Sedaght H. Emergence of high-level vancomycin-resistant Staphylococcus aureus in the Imam Khomeini Hospital in Tehran. Med Princ Pract. 2008. 17:432–434.
crossref
28. Chambers HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis. 2001. 7:178–182.
29. Hansman D. Penicillin-insensitive pneumococci. Br Med J. 1976. 2:1503–1504.
crossref
30. Jacobs MR, Koornhof HJ, Robins-Browne RM, Stevenson CM, Vermaak ZA, Freiman I, Miller GB, Witcomb MA, Isaäcson M, Ward JI, Austrian R. Emergence of multiply resistant pneumococci. N Engl J Med. 1978. 299:735–740.
crossref
31. Kim SH, Song JH, Chung DAR, Thamlikitkul V, Yang Y, Wanh H, So TM, Hsueh PR, Yasin R, Carlos CC, Van PH, Lalitha MK, Shimono N, Perera J, Shibl AM, Baek JY, Kang C, Ko KS, Peck KR. Changing trend of antimicrobial resistance and serotypes in Streptococcus pneumoniae in Asian countries: an ANSORP study. Antimicrob Agents Chemother. (in press).
32. Hsueh PR, Shyr JM, Wu JJ. Changes in macrolide resistance among respiratory pathogens after decreased erythromycin consumption in Taiwan. Clin Microbiol Infect. 2006. 12:296–298.
crossref
33. Uttley AH, Collins CH, Naidoo J, George RC. Vancomycin-resistant Enterococci. Lancet. 1988. 1:57–58.
34. Leclercq R, Derlot E, Duval J, Courvalin P. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med. 1988. 319:157–161.
crossref
35. Frieden TR, Munsiff SS, Low DE, Willey BM, Williams G, Faur Y, Eisner W, Warren S, Kreiswirth B. Emergence of vancomycin-resistant Enterococci in New York City. Lancet. 1993. 342:76–79.
36. Reik R, Tenover FC, Klein E, McDonald LC. The burden of vancomycin-resistant enterococcal infections in US hospitals, 2003 to 2004. Diagn Microbiol Infect Dis. 2008. 62:81–85.
crossref
37. Deshpande LM, Fritsche TR, Moet GJ, Biedenbach DJ, Jones RN. Antimicrobial resistance and molecular epidemiology of vancomycin-resistant Enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program. Diagn Microbiol Infect Dis. 2007. 58:163–170.
crossref
38. Werner G, Coque TM, Hammerum AM, Hope R, Hryniewicz W, Johnson A, Klare I, Kristinsson KG, Leclercq R, Lester CH, Lillie M, Novais C, Olsson-Liljequist B, Peixe LV, Sadowy E, Simonsen GS, Top J, Vuopio-Varkila J, Willems RJ, Witte W, Woodford N. Emergence and spread of vancomycin resistance among Enterococci in Europe. Euro Surveill. 2008. 13:pii: 19046.
39. Brown DF, Hope R, Livermore DM, Brick G, Broughton K, George RC, Reynolds R. BSAC Working Parties on Resistance Surveillance. Non-susceptibility trends among Enterococci and non-pneumococcal streptococci from bacteraemias in the UK and Ireland, 2001-06. J Antimicrob Chemother. 2008. 62:Suppl 2. ii75–ii85.
40. Bonten MJ, Willems R, Weinstein RA. Vancomycin-resistant Enterococci: why are they here, and where do they come from? Lancet Infect Dis. 2001. 1:314–325.
crossref
41. Klare I, Badstübner D, Konstabel C, Böhme G, Claus H, Witte W. Decreased incidence of VanA-type vancomycin-resistant Enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry. Microb Drug Resist. 1999. 5:45–52.
crossref
42. Salgado CD, Farr BM. Outcomes associated with vancomycin-resistant Enterococci: a meta-analysis. Infect Control Hosp Epidemiol. 2003. 24:690–698.
crossref
43. DiazGranados CA, Zimmer SM, Klein M, Jernigan JA. Comparison of mortality associated with vancomycin-resistant and vancomycin-susceptible enterococcal bloodstream infections: a meta-analysis. Clin Infect Dis. 2005. 41:327–333.
crossref
44. Park JW, Kim YR, Shin WS, Kang MW, Han KJ, Shim SI. Susceptibility tests of vancomycin-resistant Enterococci. Korean J Infect Dis. 1992. 24:133–137.
45. Lee K, Kim MN, Kim JS, Hong HL, Kang JO, Shin JH, Park YJ, Yong D, Jeong SH, Chong Y. KONSAR Group. Further Increases in carbapenem-, amikacin-, and fluoroquinolone-resistant isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR study 2009. Yonsei Med J. 2011. 52:793–802.
crossref
46. Report: Data Summary from July 2009 through June 2010. Korea Nosocomial Infections Surveillance System (KONIS). Accessed 1 December 2011. Accessed at: http://www.cdc.go.kr.
47. Cheong HJ, Song JY, Eom JS, Kim WJ, Choi SJ, Choi JH, Lee H, Chung MH, Lee KM, Shin DH, Sohn BR, Choi JS, Woo HJ, Kwon JA, Lee KW, Choe KW, Park SC. Colonization rate, risk factor for acquisition and genetic diversity of vancomycin-resistant Enterococci (VRE) isolated from rectal culture of patients in intensvie care units from ten large hospitals in Korea. Korean J Infect Dis. 2002. 34:276–284.
48. Yi SH, Kim SD, Chun BC, Lee J, Kim MN. Prevalence of vanA vancomycin-resistant Enterococci and epidemiologic survey of chicken farms located in Seoul and Kyunggi province. Korean J Nosocomial Infect Control. 2007. 12:77–84.
49. Han SH, Chin BS, Lee HS, Jeong SJ, Choi HK, Kim CO, Yong D, Choi JY, Song YG, Lee K, Kim JM. Vancomycin-resistant Enterococci bacteremia: risk factors for mortality and influence of antimicrobial therapy on clinical outcome. J Infect. 2009. 58:182–190.
crossref
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