Abstract
Orthopedic infections, especially implant-associated infections, are difficult to treat. Long-term oral antibiotic, along with appropriate surgery, is often needed to eradicate infections. The question still remains which antibiotic regimen is best in this setting because of a paucity of large comparative clinical trials. I reviewed in vitro and in vivo studies evaluating the effectiveness of various oral antibiotic regimens of monotherapy or combination therapy for orthopedic infections caused by methicillin-resistant staphylococci.
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