Drug-Resistant Extrapulmonary Tuberculosis

Oh-Hyun Cho; Ki-Ho Park; Seong Yeon Park; Song Mi Moon; Yong Pil Chong; Mi-Na Kim; Sang-Oh Lee; Sang-Ho Choi; Jun Hee Woo; Yang Soo Kim; Sung-Han Kim

doi:10.3947/ic.2011.43.3.258

Journal List > Infect Chemother > v.43(3) > 1035087

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Cho, Park, Park, Moon, Chong, Kim, Lee, Choi, Woo, Kim, and Kim: Drug-Resistant Extrapulmonary Tuberculosis

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Infection & Chemotherapy

Infection & Chemotherapy 2011; 43(3): 258-261.

Published online: 29 June 2011

DOI: https://doi.org/10.3947/ic.2011.43.3.258

Drug-Resistant Extrapulmonary Tuberculosis

Oh-Hyun Cho¹, Ki-Ho Park¹, Seong Yeon Park¹, Song Mi Moon¹, Yong Pil Chong¹, Mi-Na Kim², Sang-Oh Lee¹, Sang-Ho Choi¹, Jun Hee Woo¹, Yang Soo Kim¹, Sung-Han Kim¹

¹Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

²Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Correspondence to Sung-Han Kim, MD. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-3305, Fax: +82-2-3010-6970, kimsunghanmd@hotmail.com

Received 10 February 2011 Revised 8 April 2011 Accepted 11 April 2011

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prevalence and pattern of drug-resistant extrapulmonary tuberculosis (TB) is not well characterized in Korea. Therefore, we assessed the incidence of drug resistance for extrapulmonary TB in adult patients at a tertiary hospital. We retrospectively reviewed the medical records and results of drug susceptibility test in all culture-confirmed extapulmonary TB patients during an 18-month period. Out of a total of 168 cases in which the drug susceptibility test was performed, resistance to at least one anti-TB drug was found in 15 cases (8.9%), and multidrug resistance, in which TB was resistant to at least isoniazid and rifampin, was found in 3 cases (1.8%)

Keywords: Extrapulmonary, Tuberculosis, Resistance

Figures and Tables

Table 1

Clinical Characteristics of 168 Patients with Drug Sensitive and Resistant Extrapulomonary Tuberculosis

Data presented as number (%) or numbers positive/number tested (%) unless otherwise indicated. TB, tuberculsosis; AFB, acid-fast bacilli; PCR, polymerase chain reaction.

^aPatients may have ≥1 suspected sites of infection.

^bIncluded cases with isolation of M. tuberculosis, positive M. tuberculosis polymerase chain reaction, or histologic demonstration of caseating granulmatous inflammation from the bone marrow, at least 2 noncontiguous organs, or miliary lung lesions.

Table 2

Drug Resistance Pattern of Extrapulmonary Tuberculosis

Data are presented as number (%).

INH, isoniazid; RMP, rifampin; EMB, ethambutol; PZA, pyrazinamide; SM, streptomycin; KM, kanamycin; PTH, prothionamide; OFX, ofloxacin; CNS, central Nervous System.

Table 3

Resistance Proportions of Each Anti-Tuberculosis Drug

INH, isoniazid; RMP, rifampin; EMB, ethambutol; PZA, pyrazinamide; SM, streptomycin; KM, kanamycin; PTH, prothionamide; OFX, ofloxacin.

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