Three Reinfection Cases of the Pandemic Influenza (H1N1 2009)

Tae Suk Kim; Kang Myung Ho; Kyung Ree Yim; Won Sup Oh; Sung Bin Chon; Sook-Won Ryu; Kilsoo Yie; Seung-Joon Lee

doi:10.3947/ic.2010.42.4.257

Journal List > Infect Chemother > v.42(4) > 1035022

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Kim, Ho, Yim, Oh, Chon, Ryu, Yie, and Lee: Three Reinfection Cases of the Pandemic Influenza (H1N1 2009)

Case Report

Infection & Chemotherapy

Infection & Chemotherapy 2010; 42(4): 257-261.

Published online: 30 August 2010

DOI: https://doi.org/10.3947/ic.2010.42.4.257

Three Reinfection Cases of the Pandemic Influenza (H1N1 2009)

Tae Suk Kim¹, Kang Myung Ho¹, Kyung Ree Yim¹, Won Sup Oh¹, Sung Bin Chon², Sook-Won Ryu³, Kilsoo Yie⁴, Seung-Joon Lee¹

¹Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.

²Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.

³Department of Laboratory Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.

⁴Department of Cardiothoracic Surgery, Kangwon National University College of Medicine, Chuncheon, Korea.

Correspondence to Won Sup Oh, M.D., Ph.D. Division of Infectious Diseases, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University College of Medicine, 26 Kanwondaehakgil, Chuncheon 200-947, Korea. Tel: +82-33-258-2456, Fax: +82-33-258-9471, wsoh@kangwon.ac.kr

Received 18 April 2010 Revised 9 June 2010 Accepted 10 June 2010

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Infection with influenza virus results in acquisition of immunity, preventing reinfection with the homologous virus. Although reinfection following primary infection is rare, its incidence depends on immunity of human body, antigenic diversity of influenza virus, and the presence of outbreak in the community. During the pandemic influenza (H1N1 2009), a child and two women were reinfected by H1N1 influenza virus several weeks after the primary infection, and they were successfully treated again by oseltamivir. This case series will provide additional information on diagnosis, treatment, and prevention of the pandemic influenza (H1N1 2009).

Keywords: Pandemic influenza (H1N1 2009), Reinfection, Immunity

Figures and Tables

Figure 1

(A) Electrophoresis of PCR products of cDNA after neuraminidase gene sequencing from the 2009 H1N1 influenza virus RNA. (B) Alignment results of genome segment 6 of the 2009 H1N1 influenza virus.

1, first episode of case 1; 2, second episode of case 1; 3, first episode of case 2; 4, second episode of case 2; 5, first episode of case 3; 6, second episode of case 3; L, 100 bp ladder; N, negative control. Red-lined box indicates H275Y mutation site, which is conserved in all samples of 3 cases.

Table 1

Summary of Three Reinfection Cases of the 2009 H1N1 Influenza

RT-PCR, reverse transcriptase polymerase chain reaction; Ct value, cycle threshold value (cutoff value, 42.00).

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