Journal List > Infect Chemother > v.42(1) > 1034989

Lee: Outbreaks and Control of Animal Rabies in Korea


Since rabies virus infection is fatal for both human and animals, the protective immunization by vaccines against animals is a critical importance for disease prevention and control. In Korea, recurrence of sylvatic rabies was reported in Gangwon province, which is the northern border area in 1993. During the years of 1994-2009, 417 animal rabies cases were registered in Gangwon and Gyeonggi provinces. The national animal rabies eradication program has performed to reduce rabies outbreaks by annual vaccination of dogs and cattle since 1995, and the oral vaccination of raccoon dogs with annual vaccinia-rabies glycoprotein (V-RG) bait vaccine. Additionally, serological surveillance on domestic animals has been executed since 1999 to monitor the anti-rabies antibody titers from Gangwon and Gyeonggi provinces where the vaccination campaign has been implemented.

Figures and Tables

Figure 1
Regional outbreaks of animal rabies in Korea (1993-2009.3).
Figure 2
Species of animal rabies in Korea.
Table 1
Status of rabies outbreak in Korea (AIMS)


1. World Health Organization Media Center. Babies Fact Sheet. 2001.
2. Kim CH, Lee CG, Yoon HC, Nam HM, Park CK, Lee JC, Kang MI, Wee SH. Rabies, an emerging disease in Korea. J Vet Med B Infect Dis Vet Public Health. 2006. 53:111–115.
3. Kim JH, Hwang EK, Sohn HJ, Kim DY, So BJ, Jean YH. Epidemiological characteristics of rabies in South Korea from 1993 to 2001. Vet Rec. 2005. 157:53–56.
4. Kuzmin IV, Botvinkin AD, McElhinney LM, Smith JS, Orciari LA, Hughes GJ, Fooks AR, Rupprecht CE. Molecular epidemiology of terrestrial rabies in the former Soviet Union. J Wildl Dis. 2004. 40:617–631.
5. Titoli F, Pestalozza S, Irsara A, Palliola E, Frescura T, Civardi A. Attenuated rabies virus, ERA strain, in cattle and dogs vaccinated with multiple doses. Comp Immunol Microbiol Infect Dis. 1982. 5:193–197.
6. Xiang ZQ, Knowles BB, McCarrick JW, Ertl HC. Immune effector mechanisms required for protection to rabies virus. Virology. 1995. 214:398–404.
7. Coleman PG, Dye C. Immunization coverage re-quired to prevent outbreaks of dog rabies. Vaccine. 1996. 14:185–186.
8. Rupprecht CE, Dietzschold B, Cox JH, Schneider LG. Oral vaccination of raccoons (Procyon lotor) with an attenuated (SAD-B19) rabies virus vaccine. J Wildl Dis. 1989. 25:548–554.
9. Kieny MP, Lathe R, Drillien R, Spehner D, Skory S, Schmitt D, Wiktor T, Koprowski H, Lecocq JP. Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature. 1984. 313:163–165.
10. Rupprecht CE, Wiktor TJ, Johnston DH, Hamir AN, Dietzschold B, Wunner WH, Glickman LT, Koprowski H. Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine. Proc Natl Acad Sci U S A. 1986. 83:7947–7950.
11. Orciari LA, Niezgoda M, Hanlon CA, Shaddock JH, Sanderlin DW, Yager PA, Rupprecht CE. Rapid clearance of SAG-2 rabies virus from dogs after oral vaccination. Vaccine. 2001. 19:4511–4518.
12. WHO expert consulation on rabies. 1st report, WHO Technical report series no. 931. 2005. Geneva: World Health Organization.
13. Bourhy H, Rollin PE, Vincent J, Sureau P. Comparative field evaluation of the fluorescent antibody test, virus isolation from tissue culture and enzyme immunodiagnosis for rapid laboratory diagnosis of rabies. J Clin Microbiol. 1989. 27:519–523.
14. Dean D, Abelseth M, Atanasiu P. Meslin FX, Kaplan M, Koprowski H, editors. The fluorescent antibody test. Laboratory techniques in rabies. 1996. 4th ed. Geneva, Switzerland: World Health Organization;88–95.
15. Crepin P, Audry L, Rotivel Y, Gacoin A, Caroff C, Bourhy H. Intravitam diagnosis of human rabies by PCR using saliva and cerebrospinal fluid. J Clin Microbiol. 1998. 36:1117–1121.
16. David D, Yakobson B, Rotenberg D, Dveres N, Davidson I, Stram Y. Rabies virus detection by RT-PCR in decomposed naturally infected brains. Vet Microbiol. 2002. 87:111–118.
17. Hyun BH, Lee KK, Kim IJ, Lee KW, Park HJ, Lee OS, An SH, Lee JB. Molecular epidemiology of rabies virus isolates from South Korea. Virus Res. 2005. 114:113–125.
18. Park YJ, Shin MK, Kwon HM. Genetic characterization of rabies virus isolates in Korea. Virus Genes. 2005. 30:341–347.
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