Genetic association study of single nucleotide polymorphism in dentistry

Jee-Hwan Kim; Jae-Hoon Lee

doi:10.4047/jkap.2011.49.4.341

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Kim and Lee: Genetic association study of single nucleotide polymorphism in dentistry

REVIEW ARTICLE

J Korean Acad Prosthodont 2011;49(4):341-345.

Published online: 18 December 2011

DOI: https://doi.org/10.4047/jkap.2011.49.4.341

Genetic association study of single nucleotide polymorphism in dentistry

Jee-Hwan Kim, MSD, DDS, PhD, Jae-Hoon Lee, MD, DDS, PhD^∗

Department of Prodthodontics, Yonsei University College of Dentistry, Seoul, Korea

∗Corresponding Author: Jae Hoon Lee Department of Prodthodontics, Yonsei University College of Dentistry, 134 Sinchon-dong, Seodaemum-gu, Seoul 120-752, Korea +82 2 2228 8711: e-mail, jaehoon115@yuhs.ac

Received 7 July 201117 August 2011 Accepted 15 September 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Genetic association study has been progressed in medicine along with advance in genetic technology. It focused on the individual differences in genotype due to errors occurring during DNA duplication, which can cause vulnerability to specific diseases. Polymorphism defines the varieties in phenotype due to those genetic variations. Polymorphism due to change in one DNA base sequence is called as a Single Nucleotide Polymorphism. In the near future, the evaluation of relative risk to specific disease according to SNP will be essential part of fundamental of medicine for the diagnosis, treatment and prevention. Dental caries and periodontal diseases has been first subject to genetic association study in dentistry and broaden out to other areas like bone formation and resorption. This article presents the current state of genetic association study and its application to dentistry. (J Korean Acad Prosthodont 2011;49:341-5)

Keywords: Single nucleotide polymorphism, Dentistry, Genetic variation

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Fig. 1.

Classification of SNP by location.³

Fig. 2.

Distribution of DNA according to functional location.⁴

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