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Cho, Kim, Choi, and Cho: The effect of PostGraftTM on implants were installed at the tibia of ovariectomized rats
ORIGINAL ARTICLE

J Korean Acad Prosthodont 2011;49(4):300-307.

Published online: 18 December 2011

DOI: https://doi.org/10.4047/jkap.2011.49.4.300

The effect of PostGraftTM on implants were installed at the tibia of ovariectomized rats

Chun-II Cho, DDS, MSD1, Se-Won Kim, MSD, DDS, PhD2, Yu-Sung Choi, DDS, MSD1, In-Ho Cho, DDS, MSD, PhD1, ∗

1Department of Prosthodontics, School of Dentistry, Dankook University

2Oscotec Incorporation, Cheonan, Korea

∗Corresponding Author: In-Ho Cho Department of Prosthodontics, College of Dentistry, Dankook University, 7-1, Shinbu-dong, Cheonan, 330-716, Korea +82 41 550 1974: e-mail, cho8511@dankook.ac.kr

Received 8 September 201111 October 2011       Accepted 14 October 2011

Copyright © 2011 The Korean Academy of Prosthodontics

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study evaluated PostGraftTM which enhances implant stability and bone density.

Materials and methods

Forty eight implants were installed at the tibia of ovariectomized rats. The group administrated with PostGraftTM was the experimental group, and the control group was not administrated. Implant stability was evaluated at the 2nd, 4th and 6th week by Periotest value, bone mineral density, bone-to-implant contact. These values were analyzed statistically with Mann-Whitney U test (P<.05). Histological analysis was evaluated at the 2nd, 4th and 6th week.

Results

According to the Periotest® measurement, both experimental and control groups showed decrease in values as time elapsed. Greater decrease was observed in the experimental group but there was no significant difference. By examining the radiographic images, both experimental and control groups showed tendency of increase in bone density. Greater increase was seen in the experimental group but there was no significant difference. According to the bone-to-implant contact measurement, both experimental and control groups showed increase in values as time elapsed. Greater increase was seen in the experimental group. At the 2nd and 4th week, there was no significant difference. But at the 6th week, there was significant difference (P<.05). By histological analysis, both experimental and control groups showed increase in bone formation as time elapsed. In addition, greater increase was seen in the experimental group.

Conclusion

It could be concluded that the PostGraftTM medicated group showed better results in the bone density and osseointegration. (J Korean Acad Prosthodont 2011;49:300-7)

Keywords: PostGraftTM, Implant stability, Periotest value, Bone-to-implant contact, Bone density

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Fig. 1.
Schematic diagram of experimented implant blasted with resorbable blasting media (A: Lateral view, B: Occlusal view).
jkap-49-300f1.tif
Fig. 2.
Diagram of Periotest values. Values decreased in both experimental and control groups. There was no siginificant difference (P<.05).
jkap-49-300f2.tif
Fig. 3.
Diagram of bone mineral density values measured with bone mineral densitometer. Values decreased in both experimental and control groups. There was no siginificant difference (P<.05).
jkap-49-300f3.tif
Fig. 4.
Diagram of bone to implant contact (BIC) values. Values increased in both experimental and control groups. ∗At 6th weeks, there was siginificant difference (P<.05).
jkap-49-300f4.tif
Fig. 5.
Histologic findings of control group after 2 weeks (×100, bone marrow).
jkap-49-300f5.tif
Fig. 6.
Histologic findings of experimental group after 2 weeks (×100, bone marrow).
jkap-49-300f6.tif
Fig. 7.
Histologic findings of control group after 4 weeks (×40).
jkap-49-300f7.tif
Fig. 8.
Histologic findings of experimental group after 4 weeks (×40).
jkap-49-300f8.tif
Fig. 9.
Histologic findings of control group after 2 weeks (×100, bone marrow).
jkap-49-300f9.tif
Fig. 10.
Histologic findings of experimental group after 2 weeks (×100, bone marrow).
jkap-49-300f10.tif
Fig. 11.
Histologic findings of control group after 4 weeks (×40).
jkap-49-300f11.tif
Fig. 12.
Histologic findings of experimental group after 4 weeks (×40).
jkap-49-300f12.tif
Fig. 13.
Histologic findings of control group after 4 weeks (×100, cortical bone).
jkap-49-300f13.tif
Fig. 14.
Histologic findings of experimental group after 4 weeks (×100, cortical bone).
jkap-49-300f14.tif
Fig. 15.
Histologic findings of control group after 4 weeks (×100, bone marrow).
jkap-49-300f15.tif
Fig. 16.
Histologic findings of experimental group after 4 weeks (×100, bone marrow).
jkap-49-300f16.tif
Fig. 17.
Histologic findings of control group after 6 weeks (×40).
jkap-49-300f17.tif
Fig. 18.
Histologic findings of experimental group after 6 weeks (×40).
jkap-49-300f18.tif
Fig. 19.
Histologic findings of control group after 6 weeks (×100, cortical bone).
jkap-49-300f19.tif
Fig. 20.
Histologic findings of experimental group after 6 weeks (×100, cortical bone).
jkap-49-300f20.tif
Fig. 21.
Histologic findings of control group after 6 weeks (×100, bone marrow).
jkap-49-300f21.tif
Fig. 22.
Histologic findings of experimental group after 6 weeks (×100, bone marrow).
jkap-49-300f22.tif
Table 1.
Number of specimens of classified groups (N: unit)
Group week N
2 4 6
Experimental group 8 8 8  
Control group 8 8 8  
Total 16 16 16 48
Table 2.
Results of Mann-Whitney U test for Periotest® values
Week Control group (Mean ± SD) Experimental group (Mean ± SD) P value
2 2.14 ± 2.27 1.75 ± 2.25 .48
4 -0.86 ± 1.77 -1.88 ± 2.03 .24
6 -2.63 ± 0.74 -3.38 ± 0.91 .09
Table 3.
Results of Mann-Whitney U test for bone mineral density values (unit: %
Week Control group (Mean ± SD) Experimental group (Mean ± SD) P value
2 -10.3 ± 9.6 -10.5 ± 4.2 .82
4 -20.0 ± 4.9 -18.1 ± 6.8 .43
6 -25.2 ± 7.2 -23.0 ± 9.2 .40
Table 4.
Results of Mann-Whitney U test for bone to implant contact (BIC) values (unit: %)
Week Control group (Mean ± SD) Experimental group (Mean ± SD) P value
2 52.0 ± 7.0 55.0 ± 17.0 .78
4 63.0 ± 8.0 66.0 ± 13.0 .57
6 66.0 ± 9.0 ∗82.0 ± 6.0 .03
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