Journal List > J Korean Soc Transplant > v.30(2) > 1034505

J Korean Soc Transplant. 2016 Jun;30(2):59-68. Korean.
Published online June 30, 2016.
Copyright © 2016 The Korean Society for Transplantation
Genetic Polymorphism in Proteins of the Complement System
Hyori Kim, Ph.D.,1 Dobeen Hwang, Ph.D.,2 Jungwon Han,3,4 Hwa Kyoung Lee,3,4 Won Jun Yang,3 Junyeong Jin,3,4 Ki-hyun Kim,3 Sang Il Kim,3 Duck-Kyun Yoo,3,4 Soohyun Kim,3 and Junho Chung, M.D.2,3,4,5
1Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
3Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.
4Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.
5Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.

Corresponding author: Junho Chung. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: 82-2-740-8242, Fax: 82-2-747-5769, Email:
Received June 14, 2016; Accepted June 15, 2016.


The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.

Keywords: Complement system proteins; Genetic polymorphism; Autoimmune diseases


Fig. 1
Complement cascade pathways and complement proteins. Abbreviations: C, complement component; fB, factor B; fD, factor D; MBL, Mannose Binding Lectin; MAC, Membrane Attack Complex.
Click for larger image

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