Management of Opportunistic Infections after Organ Transplantation

Im-kyung Kim; Man Ki Ju

doi:10.4285/jkstn.2015.29.1.9

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Kim and Ju: Management of Opportunistic Infections after Organ Transplantation

Review Article

J Korean Soc Transplant 2015;29(1):9-15.

Published online: 10 March 2015

DOI: https://doi.org/10.4285/jkstn.2015.29.1.9

Management of Opportunistic Infections after Organ Transplantation

Im-kyung Kim, M.D., Man Ki Ju, M.D.

¹Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Corresponding author: Man Ki Ju, Department of Surgery, Gangnam Severance Hospital, 211 Eonjuro, Gangnam-gu, Seoul 135-720, Korea Tel: 82-2-2019-3893, Fax: 82-2-3462-5994 E-mail: mkju@yuhs.ac

Received 24 February 2015 Revised 4 March 2015 Accepted 4 March 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Solid organ transplantation is a therapeutic option for end-stage organ diseases. However, complications including infection and graft rejection, which are related to immunosuppressive therapy, remain the major causes of morbidity and mortality following solid organ transplantation. The optimal approach to infection in solid organ transplant recipients is prevention; failing this, prompt and aggressive diagnosis and therapy are essential. In addition, the epidemiology of infections after solid organ transplantation has shifted as a result of changes in immunosuppressive strategies and improved survival. Immunosuppression must be linked with appropriate vaccinations, donor and recipient screening, patient education regarding infectious risks and lifestyle, monitoring, and antimicrobial prophylaxis.

Keywords: Organ transplantation, Infection, Immunosuppression

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