Journal List > J Korean Soc Transplant > v.29(2) > 1034477

J Korean Soc Transplant. 2015 Jun;29(2):49-53. Korean.
Published online June 30, 2015.  https://doi.org/10.4285/jkstn.2015.29.2.49
Copyright © 2015 The Korean Society for Transplantation
Metabolomics Research in Kidney Transplantation
Yu Ho Lee, M.D.,1 and Sang Ho Lee, M.D.2
1Department of Nephrology, Kyung Hee University College of Medicine, Seoul, Korea.
2Department of Nephrology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

Corresponding author: Sang Ho Lee. Department of Nephrology, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 134-727, Korea. Tel: 82-2-440-6121, Fax: 82-2-440-6121, Email: lshkidney@khu.ac.kr
Received June 04, 2015; Revised June 08, 2015; Accepted June 08, 2015.

Abstract

Acute and chronic immune injury, drug toxicity, and cardiovascular complications remain a critical challenge following kidney transplantation. Success from these hurdles is closely associated with the ability to monitor patients and responsively adjust their medication. Metabolic and biochemical profiling (metabolomics) may enable detection of early changes in cell signal transduction regulation and biochemistry with high sensitivity and specificity. However, metabolomics have not been studied extensively in the field of kidney transplantation. This review describes the basic principles of metabolomics, summarizes recent studies, and suggests future perspectives.

Keywords: Kidney transplantation; Metabolomics; Biological markers

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