Papular Mucinosis in a Renal Transplantation Recipient

Jae Keun Park; Mi-yeon Yu; Gunwoo Koo; Joo Hee Kwak; Jung Hoon Lee; In Sub Jung; Hyunwoo Oh; Joon-Sung Park

doi:10.4285/jkstn.2014.28.4.236

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Park, Yu, Koo, Kwak, Lee, Jung, Oh, and Park: Papular Mucinosis in a Renal Transplantation Recipient

Case Report

J Korean Soc Transplant 2014;28(4):236-240.

Published online: 10 January 2014

DOI: https://doi.org/10.4285/jkstn.2014.28.4.236

Papular Mucinosis in a Renal Transplantation Recipient

Jae Keun Park, M.D., Mi-yeon Yu, M.D., Gunwoo Koo, M.D., Joo Hee Kwak, M.D., Jung Hoon Lee, M.D., In Sub Jung, M.D., Hyunwoo Oh, M.D., Joon-Sung Park, M.D.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea

Corresponding author: Joon-Sung Park Division of Nephrology, Department of Internal Medicine, Hanyang University College of Medicine, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea Tel: 82-2-2290-8319, Fax: 82-2-2298-9183 E-mail: sjpjoon@hanyang.ac.kr

Received 7 September 2014 Revised 24 September 2014 Accepted 24 September 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Papular mucinosis (PM, scleromyxoedema) is a rare dermatologic disease. It is histologically characterized by a focal dermal deposit of mucin within the skin. Although PM is accepted as an idiopathic disease in most cases, some authors argued that it may be a cutaneous manifestation of a systemic disease. Here, we describe a 68-year-old male kidney transplantation recipient with a complaint of intractable itching sensation on the forehead. We diagnosed the skin lesions as PM, which were improved after cyclosporine dose reduction.

Keywords: Papularmucinosis, Kidney transplantation, Cyclosporine

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Fig. 1.

(A) Multiple, relatively well-demarcated, flesh or erythematous colored papules on the forehead. (B) Facial dome-shaped, skin-colored papules resolved 2 weeks after reduction of cyclosporine.

Fig. 2.

A skin biopsy specimen shows (A) intact epidermis, deposition of mucinous materials (HE stain, ×40). (B) Deposition of mucinous materials between the collagen bundles and around the sweat glands (HE stain, ×100).

Fig. 3.

Histopathologic specimens. (A) Alcian blue staining showing the deposits of mucin in the dermis (×40). (B) Alcian blue positive mucin deposits were found in the dermis (×100).

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