ABO-Incompatible Living Donor Liver Transplantation

Jong Man Kim

doi:10.4285/jkstn.2014.28.1.1

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Kim: ABO-Incompatible Living Donor Liver Transplantation

Review Article

J Korean Soc Transplant 2014;28(1):1-4.

Published online: 10 March 2014

DOI: https://doi.org/10.4285/jkstn.2014.28.1.1

ABO-Incompatible Living Donor Liver Transplantation

Jong Man Kim, M.D., Ph.D.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Correspondence：Jong Man Kim, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Tel: +82-2-3410-1719, Fax: +82-2-3410-0040 E-mail: yjongman21@gmail.com

Received 5 March 2014 Revised 10 March 2014 Accepted 10 March 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Poor results after ABO-incompatible living donor liver transplantation (LDLT) are closely associated with severe hyperacute rejection due to the presence of anti-donor ABO antibodies during the early postoperative period. Nonetheless, ABO-incompatible LDLT has not been abandoned, and several different protocols have been proposed with the aim of avoiding acute graft necrosis and chronic biliary damage, both of which are recognized as major causes of poor outcome. Plasmapheresis to decrease anti-ABO titers and rituximab prophylaxis have been utilized to improve the outcome of ABO-incompatible LDLT. The lack of alternatives to LDLT provides a strong ongoing justification for performing ABO-incompatible LDLT in Korea.

Keywords: ABO blood-group system, Rituximab, Plasmapheresis, TreatmentS

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