Journal List > J Korean Soc Transplant > v.25(1) > 1034360

Cha and Moon: Management of Posttransplantation Diabetes Mellitus (PTDM)

Abstract

New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation. As long-term posttransplant survival continues to improve, increasing attention has been placed on NODAT. Because NODAT is a potent predictor of graft failure and cardiovascular mortality in the transplant population, early detection and management of NODAT are important issues. The risk factors for NODAT in transplant recipients include older age, obesity, family history, hepatitis C virus infection, and immunosuppressive agents, such as corticosteroids and calcineurin inhibitors. Management of NODAT must be considered at the pretransplantation stage to screen high risk patients and prevent NODAT. Although NODAT management is similar to type 2 diabetes management in the general population, there are some specific considerations in NODAT management, including the immunosuppressive agent. Further studies are needed to suggest optimal management guidelines for NODAT.

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Table 1.
Treatment guideline for type 2 diabetes patients
Index Value
HbA1c <7.0%
Blood pressure  
Systolic <130 mmHg
Diastolic <80 mmHg
Lipid profile  
LDL-cholesterol <100 mg/dL, <70 mg/dL (patients with
  known cardiovascular disease)
HDL-cholesterol l >40 mg/dL (men), >50 mg/dL (women)
Triglyceride <150 mg/dL

Adapted from Diabetes Care 2011;34(Suppl 1) (58).

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