Journal List > J Korean Soc Transplant > v.25(2) > 1034358

J Korean Soc Transplant. 2011 Jun;25(2):71-75. Korean.
Published online June 30, 2011.  https://doi.org/10.4285/jkstn.2011.25.2.71
Copyright © 2011 The Korean Society for Transplantation
Pathogenesis of Transplant Glomerulopathy
Beom Jin Lim, M.D. and Hyeon Joo Jeong, M.D.
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author (Email: jeong10@yuhs.ac )
Received May 22, 2011; Accepted May 23, 2011.

Abstract

Transplant glomerulopathy is a late complication of renal transplantation. The characteristic morphology of transplant glomerulopathy includes thickening of glomerular capillary loops with double contour, and duplication of glomerular basement membrane on electron microscopy. Clinical and experimental evidences support the role of antibody-mediated immune mechanism in the development of transplant glomerulopathy. Antibody-induced endothelial cell injury is the key pathogenesis of transplant glomerulopathy. The evolution of transplant glomerulopathy in the context of immunologic injury is briefly reviewed.

Keywords: Kidney glomerulus; Kidney transplantation; Graft rejection; Humoral immunity

Figures


Fig. 1
Morphologic changes of transplant glomerulopathy. Glomerular capillary loops are thickened and show double contour (A). Electron microscopy reveals the widening of lamina rara interna and newly formed lamina densa (B). The peritubular capillary basement membrane is also multilayered (C). (A; Methenamine silver stain, ×400, B; Electron microscopy, ×3,000, C; Electron microscopy, ×10,000)
Click for larger image


Fig. 2
A proposed pathogenesis of transplant glomeruopathy.
Click for larger image

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