Journal List > J Korean Soc Transplant > v.25(1) > 1034357

J Korean Soc Transplant. 2011 Mar;25(1):38-42. Korean.
Published online March 31, 2011.  https://doi.org/10.4285/jkstn.2011.25.1.38
Copyright © 2011 The Korean Society for Transplantation
Case of ABO-Incompatible Living Donor Kidney Transplantation without Blood Products in a Jehovah's Witness
An Sook Choi, M.D., Seong Min Yu, M.D., Jin Ho Lee, M.D., Joon Suk Oh, M.D., Seong Min Kim, M.D., Yong Hun Sin, M.D., and Joong Kyung Kim, M.D.
Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea.

Corresponding author (Email: syhpmj@hanmail.net )
Received January 19, 2011; Accepted March 16, 2011.

Abstract

ABO-incompatible kidney transplantations have been performed successfully in Korea without splenectomy using plasmapheresis, anti-CD20 monoclonal antibody infusions and other immunosuppressants. However, there is no report of a case of ABO-incompatible kidney transplantation in a Jehovah's Witness. Hence, we report our experience of successful ABO-incompatible kidney transplantation without blood products in a Jehovah's Witness. The recipient was treated with six sessions of plasmapheresis and he received intravenous rituximab before transplantation. Immunosuppressive regimen consisted of tacrolimus, mycophenolate mofetil and steroid. The replacement fluid for plasmapheresis was 5%% albumin solution instead of fresh frozen plasma. We measured the clotting factors before and after plasmapheresis and used cryoprecipitate to prevent bleeding.

Keywords: ABO-incompatible kidney transplantation; Clotting factors; Jehovah's Witness

Figures


Fig. 1
Clinical Course: fibrinogen progress on plasmapheresis during pretransplantation period. Abbreviation: PP, pretransplantation plasmapheresis.
Click for larger image

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