Journal List > J Korean Soc Transplant > v.25(4) > 1034350

J Korean Soc Transplant. 2011 Dec;25(4):245-248. Korean.
Published online December 31, 2011.  https://doi.org/10.4285/jkstn.2011.25.4.245
Copyright © 2011 The Korean Society for Transplantation
Paranasal Aspergillosis in Patients Prior to Liver Transplantation
Bum Gyoon Kim, M.D., Youngnam Roh, M.D., Hyunghwan Moon, M.D., Tae-Seok Kim, M.D., Sanghoon Lee, M.D., Sanghyun Song, M.D., Milljae Shin, M.D., Jong Man Kim, M.D., Choon Hyuck David Kwon, M.D., Sung Joo Kim, M.D., Jae-Won Joh, M.D., and Suk-Koo Lee, M.D.
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Corresponding author (Email: jw.joh@samsung.com )
Received September 13, 2011; Accepted November 28, 2011.

Abstract

Background

Aspergillosis infection is associated with high morbidity and mortality in liver transplant recipients. This study investigated the prognosis of liver transplant recipients with a pre-operative treatment for paranasal aspergillosis.

Methods

We collected data from 979 cases of patients who underwent liver transplants at the Samsung Medical Center from May 1996 to Feburary 2010.

Results

Eight patients were diagnosed with paranasal aspergillosis after functional endoscopic sinus surgery (FESS), before liver transplantation. In these 8 patients, 7 (87.5%) were male, with a mean age of 55 years. All patients had a hepatitis B virus infection, and 6 patients had hepatocellular carcinoma. The mean days from FESS to liver transplantation was 31 (range, 12~47 days) and anti-fungal agents were not used during these periods. All 8 patients were free from a recurrence of aspergillosis after liver transplantation.

Conclusions

Surgical treatment for paranasal aspergillosis in patients prior to liver transplantation does not induce aspergillosis infection after transplantation.

Keywords: Fungal infection; Liver transplantation; Aspergillosis; Functional endoscopic sinus surgery

Figures


Fig. 1
OMU-CT shows the calcification of left maxillary sinus.
Click for larger image


Fig. 2
Microscopic finding of paranasal aspergilloma shows fungal hyphae (Periodic Acid-Schiff Stain).
Click for larger image

Tables


Table 1
Clinical characteristics of recipient with aspergillosis after liver transplantation
Click for larger image

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