Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Hee-Yeon Kim; Jong-Young Choi

doi:10.4285/jkstn.2010.24.2.73

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Kim and Choi: Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Review Article

J Korean Soc Transplant 2010;24(2):73-79.

Published online: 10 June 2010

DOI: https://doi.org/10.4285/jkstn.2010.24.2.73

Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Hee-Yeon Kim, M.D., Jong-Young Choi, M.D.

Department of Internal Medicine, The Catholic University of Korea College of Medicine, Center for Liver Transplantation, Seoul St. Mary’ s Hospital, Seoul, Korea

책임저자：최종영, 서울시 서초구 반포동 505 가톨릭대학교 서울성모병원 소화기내과, 137-701 Tel: 02-2258-2073, Fax: 02-3481-4025 E-mail: jychoi@catholic.ac.kr 2010년 춘계 이식학회에서 발표한 내용임.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.

Keywords: Hepatitis B core antibody positive donor, Prophylaxis, De novo hepatitis B, Liver transplantation

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Fig. 1.

Risk of de novo hepatitis B infection in HBsAg-negative recipients after liver transplantation using anti-HBc positive liver graft without HBV prophylaxis in relation to pretransplant HBV serology of recipient. Abbreviations: HBsAg, hepatitis B surface antigen; anti-HBc, hepatitis B core antibody; HBV, hepatitis B virus; LT, liver transplantation. Reprinted from Fig. 1 of reference [10].

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