Journal List > J Korean Soc Transplant > v.24(2) > 1034330

Kim and Choi: Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Abstract

The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.

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Fig. 1.
Risk of de novo hepatitis B infection in HBsAg-negative recipients after liver transplantation using anti-HBc positive liver graft without HBV prophylaxis in relation to pretransplant HBV serology of recipient. Abbreviations: HBsAg, hepatitis B surface antigen; anti-HBc, hepatitis B core antibody; HBV, hepatitis B virus; LT, liver transplantation. Reprinted from Fig. 1 of reference [10].
jkstn-24-73f1.tif
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