Journal List > J Korean Soc Transplant > v.23(2) > 1034285

J Korean Soc Transplant. 2009 Sep;23(2):149-153. Korean.
Published online September 30, 2009.
Copyright © 2009 The Korean Society for Transplantation
Comparison of New Onset Diabetes according to the Time of Onset in Kidney Transplant Recipients
Kyu Jong Yoon, M.D.,1 Jun Ho Park, M.D.,1 Doo Jin Kim, M.D.,1 Sung Gil Park, M.D.,1 Jeong Hoon Lee, M.D.,1 Joo Seop Kim, M.D.,1 Suk Ja Hyun, R.N.,2 and Samuel Lee, M.D.1
1Department of Surgery, University of Hallym College of Medicine, Seoul, Korea.
2Transplantation Center of Kang-dong Sacred Heart Hospital, Seoul, Korea.

Corresponding author (Email: )
Received May 29, 2009; Accepted August 16, 2009.



New onset diabetes is a common complication after kidney transplantation. However, the clinical course of post-transplant diabetes mellitus (PTDM) remains unclear. The aim of the present study is to analyze the natural courses and risk factors of PTDM according to the time of onset.


A total of 216 consecutive kidney transplant recipients were enrolled and patient medical records were investigated retrospectively. PTDM was defined as glucose ≥126mg without previous diabetic history. Patients were classified according to the onset (12 months): early PTDM (E-PTDM) and late PTDM (L-PTDM).


PTDM was observed in 34 (17.4%) patients. The number of E-PTDM and L-PTDM patients was 17 and 17. Compared with normoglycemic patients, the PTDM group was older and showed higher pre-transplant HbA1c level. The use of tacrolimus was associated with the development of E-PTDM (OR=4.87, 1.71~13.8 in 95% CI) but not L-PTDM (OR=0.34, 0.04~2.70 in 95% CI)


The development of E-PTDM and L-PTDM may have different risk factors. It will be important to choose different therapeutic strategy according to the onset of PTDM.

Keywords: Renal transplantation; Post-transplantation diabetes mellitus; Risk factor


Table 1
Baseline clinical characteristics in Non-PTDM vs. PTDM
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Table 2
Clinical characteristics of different courses of PTDM at 1 year posttranplant
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Table 3
Risk factors associated with overall PTDM development
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Table 4
Risk factors associated with the E-PTDM development
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Table 5
Risk factors associated with L-PTDM development
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