Posttransplant Diabetes Mellitus

Hye Soo Kim; Suk Young Kim

doi:10.4285/jkstn.2009.23.2.123

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Kim and Kim: Posttransplant Diabetes Mellitus

Review Article

J Korean Soc Transplant 2009;23(2):123-129.

Published online: 11 September 2009

DOI: https://doi.org/10.4285/jkstn.2009.23.2.123

Posttransplant Diabetes Mellitus

Hye Soo Kim, M.D., Suk Young Kim, M.D.

Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea

책임저자：김석영, 대전시 중구 대흥동 520-2 대전성모병원, 가톨릭대학교 의과대학 내과학교실, 301-723 Tel: 042-220-9518, Fax: 042-255-8663 E-mail: alterego54@catholic.ac.kr

Received 17 September 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The new onset diabetes mellitus after transplantation is common and contributes to recipient morbidity and mortality. Here, we describe the prevalence, risk factors, pathogenesis, influence on outcomes, diagnosis, and treatment of posttransplant diabetes mellitus.

Keywords: Posttransplant diabetes mellitus, Prevalence, Immunosuppressant

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Fig. 1.

Pathogenic mechanisms leading to transplant associated hyperglycemia in kidney transplant recipients. Adapted from reference (8).

Table 1.

WHO and American Diabetes Association (ADA) criteria for diagnosis of diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance

	Concentration	Classification
Fasting plasma	＜100	Normal
glucose (mg/dl)	100∼125	Impaired fasting glucose (IFG)
	＞126	Diabetes mellitus
2-h glucose after	＜140	Normal
75 g oral glucose load (mg/dl)	140∼199	Impaired glucose tolerance (IGT)
	＞200	Diabetes mellitus

Table 2.

Summary of 2008 ADA recommendations for adults with diabetes

HbA1C	＜7.0%
Preprandial capillary plasma glucose	70∼130 mg/dl (3.9∼7.2 mmol/L)
Peak postprandial capillary plasma glucose	＜180 mg/dl (＜10.0 mmol/L)
Blood pressure	＜130/80 mmHg
LDL cholesterol	＜100 mg/dl (＜2.6 mmol/L)

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