Journal List > J Bacteriol Virol > v.46(4) > 1034234

J Bacteriol Virol. 2016 Dec;46(4):283-287. Korean.
Published online December 31, 2016.
Copyright © 2016 The Korean Society for Microbiology and The Korean Society of Virology
Prevalence of Hepatitis B Virus and HIV Co-infection in Korea
Hyun-Ho Lee, Hae-Guen Hong, Jong-Seong Son, Sun-Mok Kwon, Bu-Geon Lim, Kang-Bum Lee and Gu-Hwan Kim
Microbiological Inspection Team, Gyeonggi-do Research Institute of Health & Environment, Uijeongbu, Korea.

Corresponding author: Hyun-Ho Lee. Microbiological Inspection Team, Gyeonggi-do Research Institute of Health & Environment, Uijeongbu, 16205, Korea. Phone: +82-31-8030-5925, Fax: +82-31-8030-5929, Email:
Received July 27, 2016; Revised October 13, 2016; Accepted October 24, 2016.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (


Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) have a common route like sexually transmitted infections (STIs), vertical transmission and blood transfusion, etc. Therefore, it was necessary to be an attempt to confirm the relationship of HBV and HIV in Korea. We investigated the prevalence of Hepatitis B surface antigen (HBsAg) and Hepatitis B core antibody (anti-HBc) in HIV positive groups (n=430) and HIV negative groups (n=434) from January 2014 to October 2015. When comparing the prevalence of anti-HBc between the two groups, HIV positive group (36.0%) showed a higher prevalence than HIV negative group (24.7%), the result was statistically significant (p < 0.05). However, there was a little difference on HBsAg and not significant. Therefore, by showing a clear difference in anti-HBc between the two groups of HIV in Korea, it was confirmed to be associated with co-infections between Hepatitis B and HIV.

Keywords: Hepatitis B; HIV; HBsAg; Anti-HBc


Figure 1
Prevalence of HBsAg and anti-HBc according to HIV groups.
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Figure 2
Prevalence of the combination of HBsAg and anti-HBc according to HIV groups.
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Table 1
Prevalence of HBsAg according to periods (modified from ref. 17)
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1. Dienstag JL. Acute Viral Hepatitis. In: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J, editors. Harrison's Principles of Internal Medicine. 19e. New York, NY: McGraw-Hill; 2015.
2. Fauci AS, Lane H. Human Immunodeficiency Virus Disease: AIDS and Related Disorders. In: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J, editors. Harrison's Principles of Internal Medicine. 19e. New York, NY: McGraw-Hill; 2015.
3. Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol 2006;44 1 Suppl:S6–S9.
4. Kim O, Kim SS, Park MS, Suh SD, Lee MW, Kim KS, et al. Seroprevalence of sexually transmitted viruses in Korean populations including HIV-seropositive individuals. Int J STD AIDS 2003;14:46–49.
5. Centers for Disease Control and Prevention. HIV and Viral Hepatitis fact sheet. 2016 Jun;
6. Wu S, Yan P, Yang T, Wang Z, Yan Y. Epidemiological profile and risk factors of HIV and HBV/HCV co-infection in Fujian Province, southeastern China. J Med Virol. 2016 [doi: 10.1002/jmv.24666]
7. Tsuchiya N, Pathipvanich P, Rojanawiwat A, Wickukchinda N, Koga I, Koga M, et al. Chronic Hepatitis B and C co-infection increased all-cause mortality in HAART-naïve HIV patients in Northern Thailand. Epidemiol Infect 2013;141:1840–1848.
8. Nyirenda M, Beadsworth MB, Stephany P, Hart CA, Hart IJ, Munthali C, et al. Prevalence of Infection with hepatitis B and C virus and coinfection with HIV in medical inpatients in Malawi. J Infect 2008;57:72–77.
9. Desalegn Z, Wassie L, Beyene HB, Nihret A, Ebstie YA. Hepatitis B and human immunodeficiency virus co-infection among pregnant women in resource-limited high endemic setting, Addis Ababa, Ethiopia: implications for prevention and control measures. Eur J Med Res 2016;21:16.
10. Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, et al. T cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunol 2016;29:464–470.
11. Vargas JI, Jensen D, Sarmiento V, Peirano F, Acuna P, Fuster F, et al. Presence of anti-HBc is associated to high rates of HBV resolved infection and low threshold for Occult HBV Infection in HIV patients with negative HBsAg in Chile. J Med Virol 2016;88:639–646.
12. Martins S, Livramento A, Andrigueti M, Kretzer IF, Machado MJ, Spada C, et al. The prevalence of hepatitis B virus infection markers and socio-demographic risk factors in HIV-infected patients in Southern Brazil. Rev Soc Bras Med Trop 2014;47:552–558.
13. Mudawi H, Hussein W, Mukhtar M, Yousif M, Nemeri O, Glebe D, et al. Overt and occult hepatitis B virus infection in adult Sudanese HIV patients. Int J Infect Dis 2014;29:65–70.
14. Rusine J, Ondoa P, Asiimwe-Kateera B, Boer KR, Uwimana JM, Mukabayire O, et al. High seroprevalence of HBV and HCV infection in HIV-infected adults in Kigali, Rwanda. PLoS One 2013;8:e63303.
15. Panigrahi R, Majumder S, Gooptu M, Biswas A, Datta S, Chandra PK, et al. Occult HBV infection among anti-HBc positive HIV-infected patients in apex referral centre, Eastern India. Ann Hepatol 2012;11:870–875.
16. Chen X, He JM, Ding LS, Zhang GQ, Zou XB, Zheng J. Prevalence of hepatitis B virus and hepatitis C virus in patients with human immunodeficiency virus infection in Central China. Arch Virol 2013;158:1889–1894.
17. Chae HB, Kim JH, Kim JK, Yim HJ. Current status of liver diseases in Korea: hepatitis B. Korean J Hepatol 2009;15 Suppl 6:S13–S24.
18. Hong WS, Kim CY. Seroepidemiology of type A and type B hepatitis in Seoul area. Korean J Med 1982;25:19–26.
19. Jang KM, Woo SH, Yun DH, Lee KR, Kwon YO, Tae KH, et al. Seroepidemiologic survey on type B viral hepatitis in Inchon area. Korean J Med 1983;26:1331–1336.
20. Ahn YB, Mah SC. A study on the occurrence of antigen, antibody and epidemiology of hepatitis B in the life insurance company. J KLIMA 1986;3:163–169.
21. Jang MK, Lee JY, Lee JH, Kim YB, Kim HY, Lee MS, et al. Seroepidemiology of HBV infection in South Korea, 1995 through 1999. Korean J Intern Med 2001;16:153–159.
22. Joo KR, Bang SJ, Song BC, Youn KH, Joo YH, Yang SH, et al. Hepatitis B viral markers of Korean adults in the late 1990s: survey data of 70,347 health screenees. Korean J Gastroenterol 1999;33:642–652.
23. Choe BH. The epidemiology and present status of chronic hepatitis B in Korean children. Korean J Pediatr 2008;51:696–703.
24. Chun BY, Lee MK, Rho YK. The prevalence of hepatitis B surface antigen among Korean by literature review. Korean J Epidemiol 1992;14:70–78.
25. Kim RK, Ahn BM, Lee DS, Lee KM, Park YM, Lee YS, et al. Changes in the positivities of HBsAg and anti-HCV antibody among army draftees in Korea. Korean J Hepatol 2000;6:474–480.
26. Lee DH, Kim JH, Nam JJ, Kim HR, Shin HR. Epidemiological findings of hepatitis B infection based on 1998 National Health and Nutrition Survey in Korea. J Korean Med Sci 2002;17:457–462.
27. Sim JG, Seo JK, Suh SJ. Prevalence and its changes of hepatitis B viral markers from 1988 to 1993 in Korean children. J Korean Pediatr Soc 1995;38:1535–1539.
28. Choe YH, Seo JK, Yun JH, Lee HS. Recent changes in prevalence of hepatitis B viral markers in preschool children in Seoul, 1995. J Korean Pediatr Soc 1996;39:1254–1259.