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Ali and Koh: High-fat-diet-modulated Gut Microbiota Promotes Intestinal Carcinogenesis
Letter to the Editor

J Bacteriol Virol 2015;45(4):394-396.

Published online: 9 February 2015

DOI: https://doi.org/10.4167/jbv.2015.45.4.394

High-fat-diet-modulated Gut Microbiota Promotes Intestinal Carcinogenesis

Irshad Ali, Young-Sang Koh∗

Department of Microbiology and Immunology, School of Medicine and Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University, Jeju, Korea

∗Corresponding author: Young-Sang Koh. Department of Microbiology and Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 63243, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

∗∗ This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1120340).

Received 22 October 201525 October 2015       Accepted 26 October 2015

Copyright © 2015 Journal of Bacteriology and Virology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gut microbiota play a critical role in the development of intestinal cancer. Dietary changes cause dysbiosis of gut microbiota that mediates production of dietary factors triggering intestinal cancer. Genetic and dietary factors work in different combinatorial ways in initiation and progression of intestinal cancer, one of which is changes in gut microbiota. Recently, it has been found that high-fat-diet promote intestinal tumorigenesis in a genetically susceptible K-ras G12Dint mice without induction of obesity. High-fat-diet along with oncogene activation dampened paneth-cell mediated immunity and thus shift bacterial communities in such a way that promotes intestinal cancer.

Keywords: Gut microbiota, Intestinal cancer, High-fat-diet, K-ras G12Dint, Paneth cell

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