Human Norovirus Genogroups Detected from Acute Gastroenteritis Patients in Seoul from May 2013 to April 2015

Heejin Ham; Seah Oh; Hyunjung Seung; Jungim Jang; Changho Han

doi:10.4167/jbv.2015.45.4.376

Journal List > J Bacteriol Virol > v.45(4) > 1034197

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Ham, Oh, Seung, Jang, and Han: Human Norovirus Genogroups Detected from Acute Gastroenteritis Patients in Seoul from May 2013 to April 2015

Communication

J Bacteriol Virol 2015;45(4):376-381.

Published online: 9 February 2015

DOI: https://doi.org/10.4167/jbv.2015.45.4.376

Human Norovirus Genogroups Detected from Acute Gastroenteritis Patients in Seoul from May 2013 to April 2015

Heejin Ham^∗, Seah Oh, Hyunjung Seung, Jungim Jang, Changho Han

Seoul Metropolitan Government Research Institute of Public Health and Environment, Virus Team, Kyiunggido, Korea

^∗Corresponding author: Heejin Ham. Seoul Metropolitan Government Research Institute of Public Health and Environment, Virus Team, 30, Janggunmael 3 gil, Gwacheon, Kyiunggido, 13818, Korea. Phone: +82-2-968-5094, Fax: +82-2-964-8174, e-mail: hhj3814@seoul.go.kr

Received 24 June 20159 November 2015 Accepted 13 November 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Norovirus is an important cause of acute nonbacterial gastroenteritis in communities worldwide. It was evaluated the prevalence of norovirus infections in patients with acute gastroenteritis occurring in Seoul from May 2013 to April 2015, with regular surveillance. 7.3% (252/3,485) of the fecal specimens were determined to be positive for noroviruses by reverse transcriptionpolymerase chain reaction (RT-PCR). Norovirus genogroup distribution was 19.1% (48/252) genogroup GI, 71.4% (180/252) genogroup GII, and 9.5% (24/252) genogroup G1+GII respectively. It was most norovirus detection rates from November 2013 to March 2015. And it was rotavirus 0.2% (7/3,485), astrovirus 0.03% (1/3,485), sapovirus 0.03% (1/3,485) and, it was non-detective on adenovirus. Norovirus genotypes identified were nine kinds of genogroup GI (GI-1, GI-2, GI-3, GI-4, GI-6, GI-7, GI-8, GI-12, GI-14) and eight kinds of genogroup GII (GII-2, GII-3, GII-4, GII-5, GII-6, GII-7, GII-14, GII-16, GII-17). The genetic characteristics of norovirus and the epidemiological patterns of a viral pathogen from acute gastroenteritis patients may give potentially effective data for epidemiological studies in Seoul, Korea.

Keywords: Norovirus, GI, GII, RT-PCR, Gastroenteritis outbreak

REFERENCES

1). Oh SA, Park SH, Ham HJ, Seung HJ, Jang JI, Suh SW, et al. Molecular characterization of norovirus and rotavirus in outbreaks of acute gastroenteritis in Seoul. J Bacteriol Virol. 2013; 43:307–16.

2). Ham HJ, Oh SA, Kim CK, Jang JI, Jo SJ, Choi SM. Molecular characteristics of human noroviruses genogroup I and genogroup II detected in acute gastroenteritis patients in Seoul. J Environ Health Sci. 2012; 38:57–65.

3). Kim WH, Yong KC, Park PH, Kim YH, Song CS, Kim KG, et al. Genetic analysis of human noroviruses detected from acute gastroenteritis patients in Gyeonggi, Korea. J of KIHE. 2007; 20:11–8.

4). Ko EM, Seok WS, Lee TJ, Im EJ, Son SY. Epidemiological characteristics of gastroenteritis outbreaks by norovirus in Gangwondo 2007. Rep Inst Health Environ. 2008; 19:30–40.

5). Kim YJ, Lee MG, Kam SK. Characteristics of norovirus occurrence in Jeju. J Environ Sci International. 2014; 23:219–29.

6). Jung WY, Eom JH, Kim BJ, Yun MH, Ju IS, Kim CS, et al. Investigation of norovirus occurrence and influence of environmental factors in food service institutions of ChungCheng area. J Fd Hyg Safety. 2010; 25:153–61.

7). National Institute of Invironmental Research: Future Direction of Improvement in Drinking Water Safety. International Seminar on the World Water Day 2008 Manual. 2008. 125–9.

8). Kim SH, Cheon DS, Kim JH, Lee DH, Jheong WH, Heo YJ, et al. Outbreaks of gastroenteritis that occurred during school excursions in Korea were associated with several waterborne strains of Norovirus. J Clin Microbiol. 2005; 43:4836–9.

9). Ham H, Oh S, Seung H, Jo S. Molecular characteristics of noroviruses genogroup I and genogroup II detected in patients with acute gastroenteritis. Ann Lab Med. 2015; 35:242–5.

10). Kim NH, Min SK, Park EH, Park YK, Jin SH, Ryu BS. Study on gastroenteric norovirus genotypes in Busan, Korea, from 2008 to 2010. Ann Rep of Busan Met Inst Health Environ. 2010; 20:9–17.

Table 1.

Detected noroviruses from patients with acute gastroenteritis between May 2013 and April 2015 in Seoul by periodic surveillance Y∗=Year, M∗=Month

Y^∗	M^∗	No. tested samples	No. Positive (%)
Y^∗	M^∗	No. tested samples	G1	GII	GI+GII	Total
2013	May	124
	Jun	158
	Jul	50
	Aug	73	1			1
	Sep	85
	Oct	47
	Nov	147		1		1
	Dec	290		14		14
	Subtotal	974	1	15		16
2014	Jan	59
	Feb	71	4	8	3	15
	Mar	296		9	1	10
	Apr	119	1			1
	May	63	2			2
	Jun	207	1			1
	Jul	284		1		1
	Aug	268	1			1
	Sep	87		3		3
	Oct	51
	Nov	174	22	1		23
	Dec	286	8	54	11	73
	Subtotal	1,965	39	76	15	130
2015	Jan	90	1	20		21
	Feb	138	1	42	5	48
	Mar	220	6	25	4	35
	Apr	98	0	2	0	2
	Subtotal	546	8	89	9	106
	Total	3,485	48	180	24	252

Table 2.

Confirmation results on genotype of detected noroviruses from patients with acute gastroenteritis between May 2013 and April 2015 in Seoul by periodic surveillance

Type		GI (n=48)													GII (n=180)														GI+GII^∗	Total
Year	Mon.	1	2	3	4	5	6	7	8	9-12	13	14	UN^∗	M^∗	1	2	3	4	5	6	7	8-13	14	15	16	17	UN^∗	M^∗	GI+GII^∗	Total
	May
	Jun
	Jul
	Aug												1																	1
2013	Sep
	Oct
	Nov																										1			1
	Dec																	6	1	3							4			14
	Subtotal												1					6	1	3							5			16
	Jan
	Feb								1					3			2	2							2			2	3	15
	Mar																		2				5					2	1	10
	Apr				1																									1
	May				1							1																		2
	Jun						1																							1
2014	Jul																						1							1
	Aug		1																											1
	Sep																			3										3
	Oct
	Nov				22																						1			23
	Dec	2		1	2		2	1								2		8			1		4		1		34	4	11	73
	Subtotal	2	1	1	26		3	1	1			1		3		2	2	10	2	3	1		10		3		35	8	15	130
	Jan			1												1				4			7			4	4			21
	Feb	1																					3		1	37	1		5	48
2015	Mar						2				1		3										2			20	3		4	35
	Apr																											2		2
	Subtotal	1		1			2				1		3			1				4			10		1	61	8	2	9	106
	May				1							1																		2
	Jun						1																							1
	Jul																						1							1
	Aug		1										1																	2
	Sep																			3										3
Total	Oct
	Nov				22																						2			24
	Dec	2		1	2		2	1								2		14	1	3	1		4		1		38	4	11	87
	Jan			1												1				4			7			4	4			21
	Feb	1							1					3			2	2					3		3	37	1	2	8	63
	Mar						2				1		3						2				7			20	3	2	5	45
	Apr				1																							2		3
	Total	3	1	2	26		5	1	1		1	1	4	3		3	2	16	3	10	1		22		4	61	48	10	24	252
	%	1.2	0.4	0.8	10.3		2.0	0.4	0.4		0.4	0.4	1.6	1.2		1.2	0.8	6.3	1.2	4.0	0.4		8.7		1.6	24.2	19.0	4.0	9.5	100.0

^∗ UN=unknown

^∗ M=mixed

TOOLS

Similar articles