A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome

Zahid Manzoor; Young-Sang Koh

doi:10.4167/jbv.2015.45.3.282

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Manzoor and Koh: A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome

Letter to the Editor

J Bacteriol Virol 2015;45(3):282-284.

Published online: 9 February 2015

DOI: https://doi.org/10.4167/jbv.2015.45.3.282

A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome

Zahid Manzoor, Young-Sang Koh^∗

Department of Microbiology and Immunology, School of Medicine and Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University, Jeju, Korea

^∗Corresponding author: Young-Sang Koh. Department of Microbiology and Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

^∗∗ This research was supported by the 2015 scientific promotion program funded by Jeju National University.

Received 18 July 201520 July 2015 Accepted 21 July 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rheumatoid arthritis is an autoinflammatory disease that primarily affects joints and is characterized by pervasive joint inflammation. A20/Tumor necrosis factor, alpha-induced protein 3 (Tnfaip3) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and has been associated with rheumatoid arthritis. However, the precise role of A20 in rheumatoid arthritis remains unclear. Deletion of A20/Tnfaip3 gene in mice elicits impulsive erosive polyarthritis that is similar to rheumatoid arthritis in patients. Recently, it has been shown that A20 protects against arthritis by regulating the NLRP3 inflammasome.

Keywords: A20, Nod-like receptor pyrin domain-containing protein 3, Inflammasome, Rheumatoid arthritis

REFERENCES

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