Current Trends in Studies of Epstein-Barr Virus (EBV) Associated Gastric Carcinoma

Minjung Lee; Eunhyun Ryu; Gi-Ho Sung; Yu Su Shin; Jong Gwang Kim; Byung Woog Kang; Hyosun Cho; Hyojeung Kang

doi:10.4167/jbv.2015.45.3.262

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Lee, Ryu, Sung, Shin, Kim, Kang, Cho, and Kang: Current Trends in Studies of Epstein-Barr Virus (EBV) Associated Gastric Carcinoma

Research Update (Minireview)

J Bacteriol Virol 2015;45(3):262-271.

Published online: 9 February 2015

DOI: https://doi.org/10.4167/jbv.2015.45.3.262

Current Trends in Studies of Epstein-Barr Virus (EBV) Associated Gastric Carcinoma

Minjung Lee^1,^§, Eunhyun Ryu^1,^§, Gi-Ho Sung², Yu Su Shin³, Jong Gwang Kim⁴, Byung Woog Kang⁴, Hyosun Cho⁵, Hyojeung Kang^1,^∗

¹College of Pharmacy, Research Institute of Pharmaceutical Sciences, Institute for Microorganisms, Kyungpook National University, Daegu, Korea

²Institute for Bio-Medical Convergence and Institute for Integrative Medicine, International St. Mary's Hospital and College of Medicine, Catholic Kwandong University, Incheon, Korea

³Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Korea

⁴Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea

⁵College of Pharmacy, Duksung Women's University, Seoul, Korea

^∗Corresponding author: Hyojeung Kang, Ph.D. Department of Pharmacy, College of Pharmacy, Kyungpook National University, Daegu, 702-701, Korea. Phone: +82-53-950-8569, Fax: +82-53-950-8557, e-mail: hkang72@knu.ac.kr

^§ Both equally contributed.

^∗∗ This work was carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ0092412015)" Rural Development Administration, Republic of Korea.

Received 22 May 201510 June 2015 Accepted 25 June 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

EBV infection has been causally associated with incidence of many carcinomas. EBV-associated gastric carcinoma (EBVaGC) has been classified as a unique gastric carcinoma subset, suggesting EBV infection is related to the development of gastric cancer. In this study, general trends of EBVaGC studies for last half-decades were reviewed in several perspectives of clinical significance, virological importance and etiological interests. Throughout this comprehensive reviewing, new study trends of EBV and EBVaGC for next half-decades were suggested.

Keywords: Epstein-Barr virus, Human gastric carcinoma, Methylation, Prognosis

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Figure 1.

Oncogenic events to induce EBV-associated epithelial malignancies by EBV latent gene products. EBV gene products (in blue) induce malignancies by interrupting several anti-tumor activities and promoting various diverse oncogenic events in EBV infected epithelial cells.

Figure 2.

Important characteristics of gastric carcinoma subtype. Gastric carcinoma (GC) were classified into four subgroups such as chromosomally instable GC, Epstein-Barr virus (EBV)-positive GC, genomically stable GC, and microsatellite instable GC. In particular, EBV-positive GC showed mutation in PIK3CA, overexpression of PD-L1/2, silencing of CDKN2A, and etc. EBV-CIMP and RTK stand for CpG-island methylation phenotype and receptor tyrosine kinase, respectively.

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