Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus

Yeon-Soo Park; Im-Hyeon Kim; Young-Sang Koh

doi:10.4167/jbv.2014.44.2.206

Journal List > J Bacteriol Virol > v.44(2) > 1034132

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Park, Kim, and Koh: Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus

Letter to the Editor

J Bacteriol Virol 2014;44(2):206-207.

Published online: 9 February 2014

DOI: https://doi.org/10.4167/jbv.2014.44.2.206

Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus

Yeon-Soo Park, Im-Hyeon Kim, Young-Sang Koh^*

Jeju National University School of Medicine, Jeju, Korea

^*Corresponding author: Young-Sang Koh. Department of Microbiology & Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

Received 3 March 201418 March 2014 Accepted 20 March 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune responses as inhibitor of HIV reverse transcriptase blocked the induction of interferon-β by the virus. Furthermore, knockout of cGAS in human or mouse cell lines abrogated the production of cytokines by HIV infection highlighting the essential role of cGAS in detection of HIV and other retroviruses.

Keywords: cGAMP synthase (cGAS), Retroviruses, Human immunodeficiency virus, Innate immune system

REFERENCES

1). Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science. 2013; 341:903–6.

2). Wu J, Sun L, Chen X, Du F, Shi H, Chen C, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013; 339:826–30.

3). Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013; 339:786–91.

4). Barber GN. Cytoplasmic DNA innate immune pathways. Immunol Rev. 2011; 243:99–108.

5). Manel N, Littman DR. Hiding in plain sight: How HIV evades innate immune responses. Cell. 2011; 147:271–4.

6). Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010; 467:214–7.

TOOLS

Similar articles