cGAS-cGAMP Signaling and Antiviral Defense

Zahid Manzoor; Young-Sang Koh

doi:10.4167/jbv.2014.44.1.112

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Manzoor and Koh: cGAS-cGAMP Signaling and Antiviral Defense

Letter to the Editor

J Bacteriol Virol 2014;44(1):112-114.

Published online: 9 February 2014

DOI: https://doi.org/10.4167/jbv.2014.44.1.112

cGAS-cGAMP Signaling and Antiviral Defense

Zahid Manzoor, Young-Sang Koh^*

Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea

^*Corresponding author: Young-Sang Koh. Department of Microbiology and Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

^** This research was supported by the 2014 scientific promotion program funded by Jeju National University.

Received 4 January 20147 January 2014 Accepted 8 January 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas^−/- mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.

Keywords: Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), Type I interferons, DNA sensor, Antiviral defense

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