NLRP6 as a Negative Regulator of Innate Immunity

Zahid Manzoor; Young-Sang Koh

doi:10.4167/jbv.2013.43.1.64

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Manzoor and Koh: NLRP6 as a Negative Regulator of Innate Immunity

Letter to the Editor

J Bacteriol Virol 2013;43(1):64-66.

Published online: 9 February 2013

DOI: https://doi.org/10.4167/jbv.2013.43.1.64

NLRP6 as a Negative Regulator of Innate Immunity

Zahid Manzoor, Young-Sang Koh^*

Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea

^*Corresponding author: Young-Sang Koh. Department of Microbiology and Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

^** This research was supported by the 2013 scientific promotion program funded by Jeju National University.

Received 21 January 201323 January 2013 Accepted 28 January 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.

Keywords: Nod-like receptor pyrin domain-containing protein 6, Inflammasome, Listeria monocytogenes

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