PKR as a Regulator of Inflammasome Activation

Zahid Manzoor; Young-Sang Koh

doi:10.4167/jbv.2013.43.2.145

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Manzoor and Koh: PKR as a Regulator of Inflammasome Activation

Letter to the Editor

J Bacteriol Virol 2013;43(2):145-147.

Published online: 9 February 2013

DOI: https://doi.org/10.4167/jbv.2013.43.2.145

PKR as a Regulator of Inflammasome Activation

Zahid Manzoor, Young-Sang Koh^*

Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea

^*Corresponding author: Young-Sang Koh. Department of Microbiology and Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687, e-mail: yskoh7@jejunu.ac.kr

^** This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea (2010-0023645).

Received 10 May 201320 May 2013 Accepted 22 May 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1). Double-stranded RNA-dependent protein kinase (PKR) is a critical component of an inflammatory complex. Recently, the critical role of PKR was reported in regulation of multiple inflammasomes.

Keywords: Double-stranded RNA-dependent protein kinase, High-mobility group box 1, Inflammasome, Nod-like receptor family pyrin domain containing 3

REFERENCES

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