Current Understanding of Mycobacterium abscessus Infection

Go-Eun Choi; Youngsuk Jo; Sung Jae Shin

doi:10.4167/jbv.2012.42.1.17

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Choi, Jo, and Shin: Current Understanding of Mycobacterium abscessus Infection

Review Article

Journal of Bacteriology and Virology

Journal of Bacteriology and Virology 2012; 42(1): 17-28.

Published online: 23 March 2012

DOI: https://doi.org/10.4167/jbv.2012.42.1.17

Current Understanding of Mycobacterium abscessus Infection

Go-Eun Choi^1,^†, Youngsuk Jo^2,^†, Sung Jae Shin³

¹Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea.

²Research Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

³Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author: Sung Jae Shin. Department of Microbiology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Phone: +82-2-2228-1813, Fax: +82-2-392-7088, sjshin05@gmail.com

Equal contributor:

†These authors contributed equally to the work.

Received 2 March 2012 Revised 8 March 2012 Accepted 12 March 2012

Abstract

Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) that cause a broad spectrum of infections in humans. In addition, the association of M. abscessus with the cause of community- and hospital-acquired infections has been recently reported. In fact, M. abscessus is known to be the most drug-resistant mycobacterium and naturally resistant to first-line anti-tuberculous drugs, resulting in the limited therapeutic options and a high failure rate of treatment response. Three closely related species; M. abscessus (sensu stricto), M. bolletii, and M. massiliense are currently identified however, consensus on the naming of M. abscessus-related species has not been made to date. We herein discuss the advanced understanding of the virulence potentials and pathophysiological features of M. abscessus to establish novel therapeutic strategies for M. abscessus infection.

Keywords: Mycobacterium abscessus, Mycobacterium bolletii, Mycobacterium massiliense, Infection, Pathophysiology

Figures and Tables

Table 1

Nosocomial infections and outbreaks due to Mycobacterium abscessus after 2000s. Number of subspecies caused by M. abscessus infection was recorded according to the each reference, regardless of the present criteria.

Table 2

Antibiotic susceptibility of three sub-species belonging to Mycobacterium abscessus group and the related mechanism to each antibiotic.

Notes

This study was financially supported by research fund of Chungnam National University in 2011.

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