Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

Young-Sang Koh

doi:10.4167/jbv.2011.41.2.131

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Koh: Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

Letter to the Editor

J Bacteriol Virol 2011;41(2):131-132.

Published online: 18 January 2011

DOI: https://doi.org/10.4167/jbv.2011.41.2.131

Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

Young-Sang Koh^∗

Department of Microbiology & Immunology, Jeju National University School of Medicine, Jeju, Korea

^∗Corresponding author: Young-Sang Koh. Department of Microbiology & Immunology, Jeju National University School of Medicine, 102 Jejudaehakno, Jeju 690-756, Korea. Phone: +82-64-754-3851, Fax: +82-64-702-2687 e-mail: yskoh7@jejunu.ac.kr

Revised 2 May 20115 May 2011 Accepted 9 May 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3 was required for TLR9 trafficking and the production of type I interferon but not for proinflammatory cytokines. This suggests that TLR9 signaling is regulated by the subcellular localization of the receptor.

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Keywords: Toll-like receptor 9, Membrane trafficking, Adaptor complex AP-3

REFERENCES

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3). Tabeta K., Hoebe K., Janssen EM., Du X., Georgel P., Crozat K, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol. 2006. 7:156–64.

4). Kim YM., Brinkmann MM., Paquet ME., Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008. 452:234–8.

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