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Yang, Kweon, Kim, Park, So, and Song: Serological Survey of Bovine Coronavirus in Korea
Original Article

J Bacteriol Virol 2007;37(2):105-109.

Published online: 18 February 2007

DOI: https://doi.org/10.4167/jbv.2007.37.2.105

Serological Survey of Bovine Coronavirus in Korea

Dong-Kun Yang1, ∗, Chang-Hee Kweon1, Byoung-Han Kim2, Jeong-Kyu Park1, Byung-Jae So1, Jae-Young Song2

1Animal Disease Diagnosis Division, National Veterinary Research and Quarantine Service, 480 Anyang 6-dong Anyang, Gyeonggi-do 430-824, Korea

2Virology Division, National Veterinary Research and Quarantine Service, 480 Anyang 6-dong Anyang, Gyeonggi-do 430-824, Korea

∗Corresponding author: Dong-Kun Yang. National Veterinary Research and Quarantine Service, 480 Anyang 6-dong Anyang, Gyeonggi-do 430-824, Korea. Phone: +82-31-4671792, Fax: +82-31-4671868, e-mail: yangdk@nvrqs.go.kr

∗∗ This work was supported by a grant from NVRQS, Korea.

Received 13 March 2007       Accepted 12 June 2007

Copyright © 2007 Journal of Bacteriology and Virology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bovine coronavirus (BCoV) is a causative agent of entero-pathogenic diarrhea in young calves and winter dysentery (WD) in adult cattle. In this study, we conducted a nationwide sero-epidemiological survey of BCoV infection in Korea. In total, 3,029 bovine sera collected between October and December 2005 were screened for the presence of antibodies against BCoV using a hemagglutination inhibition (HI) test. Half (50.0%) of individual cattle tested were positive for BCoV. The regional distribution of the seroprevalence of positive HI antibodies was 55.7% (234/420) in Gyeonggi, 53.0% (316/596) in Jeonra, 51.9% (374/720) in Chungcheong, 48.5% (401/827) in Gyeongsang, 43.9% (79/180) in Jeju, and 38.1% (109/286) in Gangwon Province. Analyzing the distribution of HI titer according to the age of the cattle showed the highest BCoV seropositive rate in 5-year-old cattle, and the incidence of cattle with an HI antibody titer of 1:160 or above was 12.1%.

Keywords: Bovine coronavirus, Seroepidemiology, Korea

References

1). 김병한. 최근 3년간 동물용생물학적제제 수급동 향. 수의과학검역정보지. 24:67–76. 2004.
2). Alenius S, Niskanen R, Juntti N, Larsson B. Bovine coronavirus as the causative agent of winter dysentery: serological evidence. Acta Vet Scand. 32:163–170. 1991.
3). Chung CW, CHo JJ, Cho IS, An SH, Jang MS. Isolation and characterization of Bovine coronavirus from calves and adult cows with diarrhea. RDA J Veterinary Sci. 39:11–18. 1997.
4). El-Ghorr AA, Snodgrass DR, Scott FM, Campbell I. A serological comparison of bovine coronavirus strains. Arch Virol. 104:241–248. 1989.
5). Fukutomi T, Tsunemitsu H, Akashi H. Detection of bovine coronaviruses from adult cows with epizootic diarrhea and their antigenic and biological diversities. Arch Virol. 144:997–1006. 1999.
crossref
6). Ganaba R, Belanger D, Dea S, Bigras-Poulin M. A seroepidemiological study of the importance in cow-calf pairs of respiratory and enteric viruses in beef operations from northwestern Quebec. Can J Vet Res. 59:26–33. 1995.
7). Hasoksuz M, Lathrop SL, Gadfield KL, Saif LJ. Isolation of bovine respiratory coronaviruses from feedlot cattle and comparison of their biological and antigenic properties with bovine enteric coronaviruses. Am J Vet Res. 60:1227–1233. 1999.
8). Hirano N, Ono K. A serological survey of human coronavirus in pigs of the Tohoku District of Japan. Adv Exp Med Biol. 440:491–494. 1998.
crossref
9). Hussain KA, Storz J, Kousoulas KG. Comparison of bovine coronavirus (BCV) antigens: monoclonal antibodies to the spike glycoprotein distinguish between vaccine and wild-type strains. Virology. 183:442–445. 1991.
crossref
10). Jeong JH, Kim GY, Yoon SS, Park SJ, Kim YJ, Sung CM, Jang OJ, Shin SS, Koh HB, Lee BJ, Lee CY, Kang MI, Kim HJ, Park NY, Cho KO. Detection and isolation of winter dysentery bovine coronavirus circulated in Korea during 2002–2004. J Vet Med Sci. 67:187–189. 2005.
11). Kapil S, Richardson KL, Maag TR, Goyal SM. Characterization of bovine coronavirus isolates/from eight different states in the USA. Vet Microbiol. 67:221–230. 1999.
crossref
12). Ko CK, Kang MI, Lim GK, Kim GY, Yoon SS, Park JT, Jeong C, Park SH, Park SJ, Kim YJ, Jeong JH, Kim SK, Park SI, Kim HH, Kim KY, Cho KO. Molecular characterization of HE, M, and E genes of winter dysentery bovine coronavirus circulated in Korea during 2002–2003. Virus Genes. 32:129–136. 2006.
crossref
13). O'Connor A, Martin SW, Nagy E, Menzies P, Harland R. The relationship between the occurrence of undifferentiated bovine respiratory disease and titer changes to bovine coronavirus and bovine viral diarrhea virus in 3 Ontario feedlots. Can J Vet Res. 65:137–142. 2001.
14). Reynolds DJ, Debney TG, Hall GA, Thomas LH, Parsons KR. Studies on the relationship between coronaviruses from the intestinal and respiratory tracts of calves. Arch Virol. 85:71–83. 1985.
crossref
15). Saif LJ. Coronavirus immunogens. Vet Microbiol. 37:285–297. 1993.
crossref
16). Sato K, Inaba Y, Matumoto M. Serological relation between calf diarrhea coronavirus and hemagglutinating encephalomyelitis virus. Arch Virol. 66:157–159. 1980.
crossref
17). Takamura K, Okada N, Ui S, Hirahara T, Shimizu Y. Protection studies on winter dysentery caused by bovine coronavirus in cattle using antigens prepared from infected cell lysates. Can J Vet Res. 64:138–140. 2000.
18). Taniguchi S, Iwamoto H, Fukuura H, Ito H, Kaige N, Nagoto Y. Recurrence of bovine coronavirus infection in cows. J Jpn Vet Med Assoc. 39:298–302. 1986.
crossref
19). Timoney JF, Gillespie JH, Scott FW. Barlough: Bovine coronavirus infection. Pp. p. 902–905. In Hagan and Bruner's microbiology and infectious diseases of domestic animals. 8th ed.Cornell University Press;New York: 1988.
20). Traven M, Bjornerot L, Larsson B. Nationwide survey of antibodies to bovine coronavirus in bulk milk from Swedish dairy herds. Vet Rec. 144:527–529. 1999.
21). Tsunemitsu H, el-Kanawati ZR, Smith DR, Reed HH, Saif LJ. Isolation of coronaviruses antigenically indistinguishable from bovine coronavirus from wild ruminants with diarrhea. J Clin Microbiol. 33:3264–3269. 1995.
crossref
22). Tsunemitsu H, Saif LJ. Antigenic and biological comparisons of bovine coronaviruses derived from neonatal calf diarrhea and winter dysentery of adult cattle. Arch Virol. 140:1303–1311. 1995.
crossref

Figure 1.
Frequency of distribution of HI titer in 3,029 serum samples collected from Korean cattle.
jbv-37-105f1.tif
Table 1.
Cattle population and regional distribution of BCoV antibodies from cattle in Korea
Breed Province Total
GG∗ GW CC GS JR JJ
Holstein 108/156 4/7 50/106 63/137 70/131 30/70 325/607
% 69.2 57.1 47.2 46.0 53.4 42.9 53.5
Population (%)† 38.9 4.0 21.5 16.9 15.3 1.1 97.7
Korean native 126/264 105/279 324/614 338/690 246/465 49/110 1,188/2,422
% 47.7 37.6 52.8 49.0 52.9 44.6 49.1
Population (%) 6.9 8.3 19.6 32.5 26.5 1.0 94.8
Total 234/420 109/286 374/720 401/827 316/596 79/180 1,513/3,029
% 55.7 38.1 51.9 48.5 53.0 43.9 50.0

∗ GG; Gyeonggi, GW; Gangwon, CC; Chungcheong, GS; Gyeungsang, JR; Jeonra, and JJ; Jeju, respectively.

† Data was obtained from Agricultural and forestry statistical year book, National Agricultural Product Quality Management Service (March 1, 2006), Korea.

Table 2.
Age distribution of HI titer against BCoV
Age of cattle No. of positive (%) HI titer
1:20 ∼ ≤1:80 (%) ≥1:160 (%)
≤1 68/144 (47.2) 53 (38.6) 15 (10.4)
2 381/847 (45.0) 293 (34.7) 87 (10.3)
3 587/1,137 (51.6) 446 (39.2) 141 (12.4)
4 296/554 (53.4) 223 (40.3) 73 (13.2)
5 100/184 (54.3) 77 (41.8) 23 (12.5)
≥6 81/163 (49.7) 55 (33.7) 26 (16.1)
Total 1,513/3,029 (50.0) 1,148/3,029 (37.9) 365/3,029 (12.1)
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