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Son, Cho, and Pyo: Allicin Reduces Adhesion Molecules and NO Production Induced by γ irradiation in Human Endothelial Cells
Original Article

Immune Network 2002; 2(1): 6-11.

Published online: 31 March 2002

DOI: https://doi.org/10.4110/in.2002.2.1.6

Allicin Reduces Adhesion Molecules and NO Production Induced by γ irradiation in Human Endothelial Cells

Eun Wha Son1, Chul Koo Cho2, Suhk Neung Pyo1

1Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.

2Department of Radiation Oncology, Korea Cancer Center Hospital, Seoul, Korea.

Corresponding Author (snpyo@skku.ac.kr)

Copyright © 2002 The Korean Association of Immunologists

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND

Inflammation is a frequent reaction following therapeutic irradiation. Since the upregulation of adhesion molecules on endothelial cell surface is known to be associated with inflammation, the expression of adhesion molecules is an important therapeutic target.

METHODS

Treatment of human umbilical endothelial cells (HUVECs) with γ-irradiation (γIR) induces the expression of adhesion proteins such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Changes in the expression of these proteins on γ-irradiated HUVECs which had been treated previously with allicin were measured by ELISA.

RESULTS

In the present study, we demonstrate that allicin inhibits the γIR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose-dependent manner. Allicin was also found to inhibit theγIR induced production of nitric oxide (NO).

CONCLUSIONS

These data suggest that allicin has a therapeutic potential for the treatment of various inflammatory disorders associated with increase numbers of endothelial leukocyte adhesion molecules.

Keywords: Allicin, γ-irradiation, endothelial cells, ICAM-1, VCAM-1, E-selectin, NO

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