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Maeng, Lee, Cho, and Hong: Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus
Original Article

Immune Network 2002; 2(2): 115-124.

Published online: 30 June 2002

DOI: https://doi.org/10.4110/in.2002.2.2.115

Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus

Eun Ho Maeng1, Yun Tai Lee2, Kyu Bong Cho3, Seung Hee Hong4

1Korea Testing and Research Institute for Chemical Industry, Korea.

2Department of Microbiology, Dankook University, Korea.

3Department of Clinical Pathology, Shinheung College, Korea.

4National Cancer Center, Korea.

Corresponding author (mvirus@kotric.co.kr)

Copyright © 2002 The Korean Association of Immunologists

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND

The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined.

METHODS

The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines.

RESULTS

The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines.

CONCLUSION

These results suggest that the exo- secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.

Keywords: Phellinus linteus, antitumor, cytotoxicity, cytokines, immunomodulator

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