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Han, Kim, Kim, Seo, Choi, Shin, Kim, Kim, and Kim: The healing effect of rhGM-CSF on uninfected wounds
Original Article

Immune Network 2001; 1(1): 32-35.

Published online: 30 April 2001

DOI: https://doi.org/10.4110/in.2001.1.1.32

The healing effect of rhGM-CSF on uninfected wounds

Seung Kyu Han2, Byung Soo Kim1, Aeree Kim3, Jae Hong Seo1, Chul Won Choi1, Sang Won Shin1, Yeul Hong Kim1, Woo Kyung Kim2, Jun Suk Kim1

1Department of Internal Medicine, School of Medicine, Korea University, Seoul, Korea.

2Department of Plastic Surgery, School of Medicine, Korea University, Seoul, Korea.

3Department of Pathology, School of Medicine, Korea University, Seoul, Korea.

Corresponding Author (kbs0309@kumc.or.kr)

Copyright © 2001 The Korean Association of Immunologists

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing on the uninfected wounds.

Methods

Thirty Sprague-dawley white mice(250-300g) were selected in this study . The number of wound with the diameter of 5 mm, was 3 in left and 3 in right at the symmetric sites, respectively . The site of rhGM-CSF dressing was decided by a randomization. rhGM-CSF(Leucogen®) was diluted in the distilled water(5 µg/mL). The experimental wound group was dressed by l mL of distilled water mixed with rhGM-CSF and control wound group was dressed by l mL of distilled water. The dressing was done, every 24 hours. The criteria of comparison were the duration of wound healing duration, histologic findings and the bacterial culture of wound sites.

Results

The duration of wound healing was 10.3±1.7 days in experimental group and 10.2±2.8 days in control group, without significant difference. There was no specific difference of histologic findings between both groups. The pathogen was not found, at all.

Conclusion

It seems to be that rhGM-CSF has no prominent effect on the uninfected wound healing in the mice without immune suppression.

Keywords: rhGM-CSF, uninfected wound healing

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