Comparison of Clinical Manifestation and Laboratory Findings between H1N1 and Influenza B Infection

Su Hee Kim; Chul Hyue Park; Kyoung Huh; Gyu Hong Shim; Hyo-Bin Kim; Su Jeong You; Young Whan Song; Ju-Young Chung; Mi Jung Park; Chang-Keun Kim; Myoung Jae Chey; Ja Wook Koo; Sang Woo Kim

doi:10.7581/pard.2012.22.1.64

Journal List > Pediatr Allergy Respir Dis > v.22(1) > 1033211

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Kim, Park, Huh, Shim, Kim, You, Song, Chung, Park, Kim, Chey, Koo, and Kim: Comparison of Clinical Manifestation and Laboratory Findings between H1N1 and Influenza B Infection

Original Article

Pediatric Allergy and Respiratory Disease

Pediatric Allergy and Respiratory Disease 2012; 22(1): 64-70.

Published online: 31 March 2012

DOI: https://doi.org/10.7581/pard.2012.22.1.64

Comparison of Clinical Manifestation and Laboratory Findings between H1N1 and Influenza B Infection

Su Hee Kim, MD, Chul Hyue Park, MD, Kyoung Huh, MD, Gyu Hong Shim, MD, Hyo-Bin Kim, MD, Su Jeong You, MD, Young Whan Song, MD, Ju-Young Chung, MD, Mi Jung Park, MD, Chang-Keun Kim, MD, Myoung Jae Chey, MD, Ja Wook Koo, MD, Sang Woo Kim, MD

Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.

Corresponding author (hbkim@paik.ac.kr)

Received 21 September 2011 Revised 31 October 2011 Accepted 3 November 2011

Abstract

Purpose

Influenza virus is one of the most important viruses that cause the respiratory infection seasonally. In April 2009, H1N1 was detected in America and Mexico and then there was pandemic in Korea. We investigated the difference of clinical and laboratory findings between the infections of H1N1 and Influenza B.

Methods

We have retrospectively studied the patients under age of 15 years who visited Inje University Sanggye Paik Hospital from August 2009 to April 2010. Evaluation for influenza infection was performed by rapid antigen test or multiplex reverse transcriptase polymerase chain reaction. Complete blood count with differential counts, C-reactive protein and chest X-ray were checked.

Results

Enrolled patients were 2,226 in H1N1-infected group and 288 in influenza B-infected group. Seasonal variation was that H1N1 in autumn and winter but influenza B in spring. The male-to-female sex ratio was same as 1.23 in each group. The mean age of H1N1-infected group was higher than influenza B-infected group (P<0.001). Fever was developed similarly in both groups (P=0.114). However, cough, sputum, rhinorrhea, vomiting, diarrhea, and headache were more prevalent in influenza B infection compared to H1N1 infection (P<0.001). Pneumonia development and admission rate were higher in influenza B infection compared to H1N1 infection (P<0.001, respectively).

Conclusion

Although H1N1 infection spread rapidly, H1N1 caused not so severe symptoms than influenza B. Because of the possibility that influenza epidemic will develop repeatedly in the future, we need to evaluate more about different characteristics depending on the virus subtype and prepare for them.

Keywords: H1N1 influenza, Influenza B, Clinical features

Figures and Tables

Table 1

Characteristics of Patients with H1N1 and Influenza B Infection

Values are presented as mean±SD or number (%).

Table 2

Comparison of Clinical Manifestations between H1N1 and Influenza B Infection Group

Values are presented as number (%).

Table 3

Comparison of Laboratory and Radiologic Findings between H1N1 and Influenza B Infection Group

Hb, hemoglobin; WBC, white blood cell; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urine nitrogen.

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