The Level of Serum Immunoglobulin E Measured at General Hospitals in Six Regions of Korea in Children with Allergic Diseases

Joo-Hwa Kim; Kyung-Bin Choi; Jin-Hwa Moon; Ha-Baik Lee; Sung-Won Kim; Myung-Hee Kook; Ja-Kyung Kim; Woo-Kyung Kim; Yong-Min Park; So-Yeon Lee; Soo-Jong Hong; Ju-Hee Seo; Kyung Won Kim; Hyun-Hee Kim; Kangmo Ahn; Jung-Won Park; Sang-Heon Cho; Joo-Shil Lee; Eun-Jin Kim; Jae-Won Oh

doi:10.7581/pard.2012.22.1.45

Journal List > Pediatr Allergy Respir Dis > v.22(1) > 1033209

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Kim, Choi, Moon, Lee, Kim, Kook, Kim, Kim, Park, Lee, Hong, Seo, Kim, Kim, Ahn, Park, Cho, Lee, Kim, and Oh: The Level of Serum Immunoglobulin E Measured at General Hospitals in Six Regions of Korea in Children with Allergic Diseases

Original Article

Pediatric Allergy and Respiratory Disease

Pediatric Allergy and Respiratory Disease 2012; 22(1): 45-53.

Published online: 31 March 2012

DOI: https://doi.org/10.7581/pard.2012.22.1.45

The Level of Serum Immunoglobulin E Measured at General Hospitals in Six Regions of Korea in Children with Allergic Diseases

Joo-Hwa Kim, MD^l, Kyung-Bin Choi, MD^l, Jin-Hwa Moon, MD^l, Ha-Baik Lee, MD¹, Sung-Won Kim, MD², Myung-Hee Kook, MD³, Ja-Kyung Kim, MD⁴, Woo-Kyung Kim, MD⁵, Yong-Min Park, MD⁶, So-Yeon Lee, MD⁷, Soo-Jong Hong, MD⁸, Ju-Hee Seo, MD⁸, Kyung Won Kim, MD⁹, Hyun-Hee Kim, MD¹⁰, Kangmo Ahn, MD¹¹, Jung-Won Park, MD¹², Sang-Heon Cho, MD¹³, Joo-Shil Lee, PhD¹⁴, Eun-Jin Kim, PhD¹⁴, Jae-Won Oh, MD¹

¹Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.

²Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea.

³Department of Pediatrics, Gwangju Veterans Hospital, Gwangju, Korea.

⁴Department of Pediatrics, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.

⁵Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

⁶Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

⁷Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

⁸Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁹Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

¹⁰Department of Pediatrics, Bucheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Bucheon, Korea.

¹¹Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

¹²Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

¹³Department of Internal Medicine, Seoul National University University, Seoul National University College of Medicine, Seoul, Korea.

¹⁴Allergy TF, Department of Immunology and Pathology, Korea National Institute of Health, Cheongwon, Korea.

Corresponding author (jaewonoh@hanyang.ac.kr)

Received 7 September 2011 Revised 29 September 2011 Accepted 6 October 2011

Abstract

Purpose

We investigated the change in serum total immunoglobulin E (IgE) and allergen-specific IgE according to allergic diseases and age.

Methods

Allergic markers of children under 18 years of age with allergic diseases for the last 5 years were collected from 12 hospitals nationwide. The total data was 9,710. Data about levels of serum total IgE and allergen-specific IgE to 15 common allergens were collected.

Results

In children with asthma, serum total IgE was higher in older age than in younger age until age 7 to 12 years, at which time the level was highest (paper radioimmunosorbent test, 526.7 IU/mL; UniCAP, 339.9 IU/mL). The level was lower in older age than that during younger age. This change was similar to that in children with allergic rhinitis and atopic dermatitis. The level was highest at ages 7 to 12 years in children with allergic rhinitis, and at age 10 to 12 years in children with atopic dermatitis. In children with both asthma and allergic rhinitis, as well as in children with all three diseases, the change in serum total IgE was similar to that of children with an isolated disease. The highest level in children with all three diseases was higher than that in children with an isolated disease. The analysis of allergen-specific IgE positivity showed that food allergens were dominant before the age of 2 years, and that aeroallergens such as house dust mites were dominant.

Conclusion

Serum total IgE in Korean children with allergic diseases was higher in older age than in younger age until the ages of 7 to 12 years, and then the change in total IgE by age was the opposite.

Keywords: Asthma, Allergic rhinitis, Atopic dermatitis, Immunoglobulin E, Allergen-specific IgE

Figures and Tables

Fig. 1

The levels of serum total immunoglobulin G (IgE) according to age in children with asthma (A), allergic rhinitis (B) and atopic dermatitis (C) (■, paper radioimmunosorbent test; ●, UniCAP).

Fig. 2

Sensitization rate of 15 inhalant and food allergens according to age in children with asthma (A), allergic rhinitis (B) and atopic dermatitis (C). Dp, Dermatophagoides pteronyssinus; Df, Dermatophagoides farinae.

Fig. 3

The levels of serum total immunoglobulin (IgE) according to the age in patients with both asthma and allergic rhinitis (A) and patients with asthma, allergic rhinitis and atopic dermatitis (B) (■, paper radioimmunosorbent test; ●, UniCAP).

Table 1

Regions of Data Collection and Counts

Table 2

Multiple Comparison Analysis of Serum Total IgE between Disease Groups according to Age

Multiple comparison analysis was performed by Tukey's test.

IgE, immunoglobulin E; PRIST, paper radioimmunosorbent test; AS, asthma; AR, allergic rhinitis; AD, atopic dermatitis.

^* and ^† had significant difference compared with other disease groups with the same age and method.

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ORCID iDs: Woo-Kyung Kim
https://orcid.org/http://orcid.org/0000-0001-8730-010X
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