Clinical Manifestations of Respiratory Viruses in Hospitalized Children with Acute Viral Lower Respiratory Tract Infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea

Hye-Young Kim; Kyoung Min Kim; Seong Heon Kim; Seung Kook Son; Hee Ju Park

doi:10.7581/pard.2012.22.3.265

Journal List > Pediatr Allergy Respir Dis > v.22(3) > 1033183

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Kim, Kim, Kim, Son, and Park: Clinical Manifestations of Respiratory Viruses in Hospitalized Children with Acute Viral Lower Respiratory Tract Infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea

Original Article

Pediatric Allergy and Respiratory Disease

Pediatric Allergy and Respiratory Disease 2012; 22(3): 265-272.

Published online: 30 September 2012

DOI: https://doi.org/10.7581/pard.2012.22.3.265

Clinical Manifestations of Respiratory Viruses in Hospitalized Children with Acute Viral Lower Respiratory Tract Infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea

Hye-Young Kim, MD, Kyoung Min Kim, MD, Seong Heon Kim, MD, Seung Kook Son, MD, Hee Ju Park, MD

Department of Pediatrics, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea.

Corresponding author (Phj7294@hanmail.net)

Received 27 March 2012 Revised 28 June 2012 Accepted 16 July 2012

Abstract

Purpose

This study was performed to investigate the epidemiologic and clinical features of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Busan and Gyeongsangnam-do, Korea.

Methods

From May 2010 to April 2011, we tested nasopharyngeal aspiration specimens in 1,520 hospitalized children with ALRTI with multiplex real time-polymerase chain reaction (RT-PCR) to identify 7 kinds of common pathogens (adenovirus [ADV], influenza virus type A [influ A], influenza virus type B [influ B], human metapneumovirus [hMPV], parainfluenza virus [PIV], human rhinovirus [hRV], respiratory syncytial virus [RSV]). We analyzed positive rates and clinical features by retrospective review of the chart.

Results

Virus agents were isolated from 72.5% of cases. The identified pathogens were RSV, 35.5%; hRV, 25.6%; PIV, 13.8%; ADV, 12.8%; hMPV, 7.1%; influ A, 5.0%; and influ B, 0.3%. The major period of viral ALRTI was the first year of life. Clinical diagnoses of viral ALRTI were pneumonia, 52.3%; bronchiolitis, 21.2%; tracheobronchitis, 1.0%; croup, 10.8%; and asthma, 8.8%. The most frequent case of pneumonia and bronchiolitis was RSV. Croup was frequently caused by PIV. The number of hMPV infections peaked between April and June and were primarily caused due to pneumonia.

Conclusion

Although this study was confined to one year, this study described the features of ALRTI associated with 7 respiratory viruses in children in Busan and Gyeongsangnam-do, Korea. Additional investigations are required to define the role of respiratory viruses in children with ALRTI in this area.

Keywords: Respiratory tract infection, Epidemiology, Respiratory virus, RT-PCR, Children

Figures and Tables

Fig. 1

Age distribution in children with acute viral lower respiratory tract infections caused by specific viruses from 2010 to 2011. ADV, adeno-virus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumo-virus; PIV, parainfluenza virus; hRV, human rhino-virus; RSV, respiratory syncytial virus.

Fig. 2

Monthly incidence of acute lower respiratory tract infections caused by specific viral agents from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

Fig. 3

Distribution of viral agents according to clinical patterns in children with acute lower respiratory tract infections from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

Table 1

Clinical Characteristics of Acute Viral Lower Respiratory Tract Infections in Children

Values are presented as mean±standard deviation or number (%).

ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

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