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Abstract
Purpose
Influenza B-associated myositis is an infrequent and poorly known complication of influenza B virus infection in children. The aim of this study was to describe the clinical and laboratory manifestations, diagnosis, and outcomes of influenza B-associated myositis in Korean children.
Methods
A retrospective analysis was conducted in patients aged <16 years who had been diagnosed with influenza B-associated myositis at the Catholic University Bucheon Saint Marys' Hospital between April 2010 and May 2010.
Results
Overall, 16 cases were analyzed. Influenza B-associated myositis typically occurred in preschool-aged children with a 3:1 male predominance. The mean age was 4.6 years (range, 3 to 7 years). The median interval between onset of influenza infection and onset of influenza B-associated myositis was 3 days (range, 1 to 7 days). Only the calf muscles were involved in all patients. Blood creatine phosphokinase concentration was elevated in most patients. Median duration to clinical recovery was 3 days (range, 1 to 4 days). No patient had rhabdomyolysis, renal failure, or related sequelae. All patients had a favorable outcome without administration of antiviral drugs.
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Table. 1
Characteristics of the Study Population (n=16)
| Variable | Value |
|---|---|
| Gender (M/F) | 12/4 (75/25) |
| Age (yr) | 4.6 1.1 (3 ± −7) |
| Time∗ (day) | 3.6 1.5 (1 ± −7) |
| Duration† (day) | 2.6 1.0 (1 ± −4) |
| Hospital stay (day) | 5.0 1.0 (4 ± −7) |
Table.
2. Clinical Manifestations of Influenza B-Associated Myositis in Children (n=16)
| Symptom/sign | No. of patients (%) |
|---|---|
| Calf pain | 16 (100) |
| Cough | 12 (75) |
| Fever | 9 (56) |
| Sore throat | 4 (25) |
| Headache | 1 (6) |
Table.
3. Laboratory Findings on Admission
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