Impact of Nocturia on Abnormal Daytime Sleepiness in Men with Lower Urinary Tract Symptoms/Benign Prostate Hyperplasia

Seung Whan Doo; Hong Jun Lee; Won Jae Yang; Hong Cheol Ahn; Jung Hoon Kim; Si Jung Park; Jin Ahn; Yun Seob Song

doi:10.5534/kja.2012.30.1.40

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Doo, Lee, Yang, Ahn, Kim, Park, Ahn, and Song: Impact of Nocturia on Abnormal Daytime Sleepiness in Men with Lower Urinary Tract Symptoms/Benign Prostate Hyperplasia

Original Article

Korean J Androl 2012;30(1):40-44.

Published online: 17 April 2012

DOI: https://doi.org/10.5534/kja.2012.30.1.40

Impact of Nocturia on Abnormal Daytime Sleepiness in Men with Lower Urinary Tract Symptoms/Benign Prostate Hyperplasia

Seung Whan Doo¹, Hong Jun Lee², Won Jae Yang¹, Hong Cheol Ahn¹, Jung Hoon Kim^2,³, Si Jung Park^1,², Jin Ahn^1,², Yun Seob Song¹

¹Department of Urology, Soonchunhyang University School of Medicine, Korea

²Medical Research Institute, Chung-Ang University School of Medicine, Seoul, Korea

³Hankuk Academy of Foreign Studies, Yongin, Korea

Correspondence to: Yun Seob Song, Department of Urology, College of Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul, 140-743, Korea, Tel: 02-709-9376, Fax: 02-709-9377, E-mail: yssong@hosp.sch.ac.kr

Revised 13 October 201116 February 2012 Accepted 16 March 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Nocturia is one of the most bothersome lower urinary tract symptoms (LUTS). The aim of the prese study is to determine whether severe-nocturia have impact on the abnormal daytime sleepiness in men wit LUTS/benign prostate hyperplasia (BPH).

Materials and Methods

Severe-nocturia was classified as twice or more per night. A total of 85 men met th criteria and constituted the study cohort. The patients had a detailed clinical evaluation, including a complete histor physical examination, urine analysis, urine culture, a digital rectal examination, serum prostate-specific antigen (PSA level, prostate volume by transrectal ultrasonography, uroflowmetry and postvoid residual urine volume. LUTS an symptom-specific quality of life (QoL) were assessed using the IPSS. Patients were asked to complete an Epwort Sleepiness Scale questionnaire for daytime sleepiness.

Results

43 patients had less than one, 42 patients had more than two episodes of nocturia. There was no significa difference of age, total prostate volume, PSA levels between patients with mild-nocturia and severe-nocturia. Ther was no significant difference of maximum flow rate (Qmax), voided volume and postvoid residual urine volume (PV between patients with mild-nocturia and severe-nocturia. There was significant decrease of total International Prostat Symptom Score (IPSS) scores and QoL index in patients with severe-nocturia compared in patients with mild-nocturi The number of patients with abnormal daytime sleepiness in mild-nocturia and severe-nocturia were 4.7% (2/43 16.7% (7/42), respectively (p＜0.05). Regression coefficiency between percent of nocturia and total score of daytim sleepiness was significant (p＜0.05) and regression coefficient (R) was 0.29.

Conclusions

Our results indicate that severe-nocturia had impact on the abnormal daytime sleepiness in patient with LUTS.

Keywords: Nocturia, Lower urinary tract symptoms, Sleep disorders

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Fig. 1.

Daytime sleepiness. The number of patients with abnormal daytime sleepiness in with mild nocturia and with severe nocturia were 4.7% and 19.0%, respectively (Fisher's exact test, p<0.05).

Table 1.

Profines in patients with mild nocturia or severe nocturia

Variable	Mild-nocturia	Severe-nocturia	p-value
Number of patients	43	42	＞0.05
Age	62.1±1.8	63.0±1.2	＞0.05
Prostate volumes (ml)	31.3±1.5	30.1±1.8	＞0.05
PSA (ng/ml)	1.2±0.2	1.6±0.4	＞0.05
Uroflowmetry
Qmax (ml/s)	11.9±1.1	10.8±1.0	＞0.05
Voided volume (ml)	203.2±29.4	196.3±20.8	＞0.05
PVR (ml)	10.9±5.8	22.8±11.0	＞0.05
IPSS
Number of nocturia	0.58±0.10	3.24±0.16	＜0.05
Total	9.3±0.9	22.0±1.1	＜0.05
QoL index	2.4±0.2	4.4±0.2	＜0.05

Data are expressed as mean±standard error. PSA: prostate specific antigren, Qmax: maximum flow rate, PVR: postvoid residual volume, IPSS: International Prostate Symptom Score, QoL: quality of life.

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