Journal List > Korean J Androl > v.30(1) > 1033103

Yoon: Hormone Replacement Therapy in Female Sexual Dysfunction

Abstract

Female sexual function is highly complex and deeply influenced by hormonal and non-hormonal factors. As sexual dysfunction becomes a common and important problem for women of all ages with related quality of life issues, we need to understand more about the effect of sex steroid hormones in female sexual function. However, there are limited data about the correlation between the value of sex steroid hormones- testosterone, in particular-and female sexual function. In a certain type of female sexual dysfunction (FSD), hypoactive sexual desire disorder, for example, there is evidence that treatment with androgens or with estrogens is effective. To widen the therapeutic options of hormone replacement therapy in FSD, further research is needed as to the benefits and risks of hormonal treatments in both pre- and post-menopausal women. Although important unanswered questions still exist in hormonal treatment of FSD, new therapeutic strategies are being studied and many ongoing clinical trials are expecting favorable results leading to more successful treatment of FSD.

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Fig. 1.
Schematic diagram of sex steroidogenesis from cholesterol.
kja-30-13f1.tif
Table 1.
Testosterone currently available in Korea
Type of Testosterone dose Method
Testosterone undecanoate 40 mg PO
Testosterone undecanoate 250 mg/ml Intramuscular injection
Testosterone gel 1 or 2% Apply on skin
Testrogen patch 1.2∼2.4 mg/24 hr Apply on skin
Testosterone enanthate 250 mg/ml Intramuscular injection

From KIMS database

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