Journal List > Korean J Androl > v.29(3) > 1033082

Kim, Hwang, Kim, Jung, Kang, Kwon, Park, and Ryu: Clinical Significance of Transrectal Ultrasonography and Efficacy of Dutasteride Treatment in Patients with Hemospermia

Abstract

Purpose

The aims of this study were to investigate the clinical significance of transrectal ultrasonography (TRUS) and the efficacy of dutasteride (5α-reductase inhibitor) in patients with hemospermia.

Materials and Methods

From January 2005 to December 2008, 60 patients with hemospermia were enrolled in the study. All patients underwent a digital rectal examination and TRUS; serum prostate specific antigen was also measured. The management of hemospermia was one of the following: watchful waiting, dutasteride treatment, or antibiotics with dutasteride.

Results

Thirty-four patients (56.7%) had positive findings on TRUS. There were 16 cases (26.7%) of prostate calcification, 13 cases (21.7%) of ejaculatory duct cyst, 3 cases (5%) of ejaculatory duct calcification, a case of seminal vesicle inflammation, and a case of ejaculatory duct dilation. Dutasteride treatment resulted in improvement of symptoms in 87.9% (29/33) of the cases, whereas treatment with antibiotics or antibiotics with dutasteride resulted in a 100% (6/6) success rate. However, among 14 watchful waiting patients, only 3 patients (21.4%) showed an improvement of symptoms.

Conclusions

This study showed that TRUS is an easy and effective method for the assessment of hemospermia, and also revealed that dutasteride could be a useful agent in the treatment of hemospermia.

REFERENCES

1). Master VA, Turek PJ. Ejaculatory physiology and dysfunction. Urol Clin North Am. 2001; 28:363–75.
crossref
2). Papp G, Molnar J. Causes and differentialdiagnosis of hematospermia. Andrologia. 1981; 13:474–8.
crossref
3). Littrup PJ, Lee F, McLeary RD, Wu D, Lee A, Kumasaka GH. Transrectal US of the seminal vesicles and ejaculatory ducts: clinical correlation. Radiology. 1988; 168:625–8.
crossref
4). Worischeck JH, Parra RO. Chronic hematospermia: assessment by transrectal ultrasound. Urology. 1994; 43:515–20.
crossref
5). Lu CH, Chen WC, Wu HC, Lu HF. Transrectal ultrasonographic findings in patients with hemospermia. Zhonghua Yi Xue Za Zhi (Taipei). 2000; 63:558–62.
6). Cho IR, Jeong JY, Rha KH, Lee MS. Usefulness of transrectal ultrasonography (TRUS) and transurethral ultrasonography (TUUS) in diagnosis and treatment of hemospermia ssociated with prostatic midline cysts. J Korean Androl Soc. 1997; 15:151–6.
7). Cho IR, Lee MS, Rha KH, Hong SJ, Park SS, Kim MJ. Magnetic resonance imaging in hemospermia. J Urol. 1997; 157:258–62.
crossref
8). Leskinen M, Lukkarinen O, Marttila T. Effects of finasteride in patients with inflammatory chronic pelvic pain syndrome: a double-blind, placebo-controlled, pilot study. Urology. 1999; 53:502–5.
crossref
9). Kaplan SA, Volpe MA, Te AE. A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis/chronic pelvic pain syndrome. J Urol. 2004; 171:284–8.
crossref
10). Nickel JC, Downey J, Pontari MA, Shoskes DA, Zeitlin SI. A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis). BJU Int. 2004; 93:991–5.
crossref
11). Marshall S, Narayan P. Treatment of prostatic bleeding: suppression of angiogenesis by androgen deprivation. J Urol. 1993; 149:1553–4.
crossref
12). Miller MI, Puchner PJ. Effects of finasteride on hematuria associated with benign prostatic hyperplasia: longterm follow-up. Urology. 1998; 51:237–40.
crossref
13). Yu HH, Wong KK, Lim TK, Leong CH. Clinical study of hemospermia. Urology. 1977; 10:562–3.
crossref
14). Leary FJ, Aguilo JJ. Clinical significance of hematospermia. Mayo Clin Proc. 1974; 49:815–7.
15). Gerber GS, Brennder CB. Evaluation of the urologic patient: history, physical examination and urinalysis. Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Campbell-Walsh urology. 9th ed.Philadelphia: Saunders;2007. 87.
16). Jones DJ. Haemospermia: a prospective study. Br J Urol. 1991; 67:88–90.
crossref
17). Byon SK, Rha KH, Yang SC. Transutricular seminal-vesicu- loscopy in the management of hematospermia. Korean J Urol. 2001; 42:329–33.
18). Kim JY, Park SS. The findings of transrectal ultrasonography in evaluation of organic hemospermia. Korean J Urol. 1993; 34:811–4.
19). Jinza S, Noguchi K, Hosaka M. Retrospective study of 107 patients with hematospermia. Hinyokika Kiyo. 1997; 43:103–7.
20). Luzzi GA. Chronic prostatitis and chronic pelvic pain in men: aetiology, diagnosis and management. J Eur Acad Dermatol Venereol. 2002; 16:253–6.
crossref
21). McConnell JD, Wilson JD, George FW, Geller J, Pappas F, Stoner E. Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab. 1992; 74:505–8.
crossref
22). Cho IR, Lee KC, Jeon JS, Park SS. Effects of finasteride on hemospermia. Korean J Androl. 2004; 22:141–5.
23). Fuse H, Sumiya H, Ishii H, Shimazaki J. Treatment of hemospermia caused by dilated seminal vesicles by direct drug injection guided by ultrasonography. J Urol. 1988; 140:991–2.
crossref
24). Abe M, Watanabe H, Kojima M, Saitoh M, Ohe H. Puncture of the seminal vesicles guided by a transrectal realtime linear scanner. J Clin Ultrasound. 1989; 17:173–8.
crossref
25). Williams RD, Sandlow JI. Surgery of the seminal vesicles. Walsh PC, Retik AB, Vaugh ED, Wein AJ, editors. Campbell's urology. 7th ed.Philadelphia: Saunders;1998. p. 3308–12.
26). Yang SC, Rha KH, Byon SK, Kim JH. Transutricular seminal vesiculoscopy. J Endourol. 2002; 16:343–5.
crossref
27). Fuse H, Nishio R, Murakami K, Okumura A. Transurethral incision for hematospermia caused by ejaculatory duct obstruction. Arch Androl. 2003; 49:433–8.
crossref
28). Li L, Jiang C, Song C, Zhou Z, Song B, Li W. Transurethral endoscopy technique with a uretero-scope for diagnosis and management of seminal tracts disorders: a new approach. J Endourol. 2008; 22:719–24.
crossref

Fig. 1.
Transrectal ultrasonographic (TRUS) findings in patients with hemospermia. (A) Prostate multiple calcifications. (B) Ejaculatory duct cysts (+: ejaculatory duct cyst). (C) Ejaculatory duct calcifications. (D) Seminal vesicle calcifications. (E) Ejaculatory duct dilation.
kja-29-206f1.tif
Table 1.
Patient characteristics
Characteristics Value
Number of patients 60
Age (years) 52.21 (28∼84)
Duration of symptoms (months) 7.7 (0.03∼72)
PSA (ng/ml) 1.44 (0.22∼4.84)
Prostate volume (cc) 23.1 (11∼49)
Follow-up (month) 5.9 (2∼24)

PSA: prostate specific antigen.

Table 2.
Abnormal findings in transrectal ultrasonography
Abnormal findings No. of patients (%)
Prostate calcifications 16 (26.7)
Ejaculatory duct cysts 13 (21.7)
Ejaculatory duct calcifications s 3 (5.0)
Seminal vesicle calcifications 1 (1.7)
Ejaculatory duct dilation 1 (1.7)
Total 34 (56.7)
Table 3.
Various methods of managing hemospermia
Treatment option No. of patients (%) Duration of treatment (months) Success (%)
Dutasteride 33 (55.0) 3.98 29 (87.9)
Antibiotics 3 (5.0) 2.8 3 (100)
Dutasteride with antibiotics 3 (5.0) 3 3 (100)
Observation 14 (23.3) 2.3 3 (21.4)
Surgery 7 (11.7) - 6 (85.7)
TOOLS
Similar articles