A Case of Solitary Involved NK-T Cell Lymphoma on the Gallbladder

Hee Ja Ko; Mi Yean Yang; Han Jo Kim; Jin A Yun; Hyun Jung Kim; Sang Cheol Lee; Sang Byung Bae; Chan Kyu Kim; Nam Su Lee; Seong Kyu Park; Kyu Teak Lee; Jong Ho Won; Dae Sik Hong; Hee Sook Park; Hee Kyung Kim

doi:10.5045/kjh.2009.44.4.268

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Ko, Yang, Kim, Yun, Kim, Lee, Bae, Kim, Lee, Park, Lee, Won, Hong, Park, and Kim: A Case of Solitary Involved NK-T Cell Lymphoma on the Gallbladder

Case Report

Korean J Hematol 2009;44(4):268-272.

Published online: 20 December 2009

DOI: https://doi.org/10.5045/kjh.2009.44.4.268

A Case of Solitary Involved NK-T Cell Lymphoma on the Gallbladder

Hee Ja Ko, M.D.¹, Mi Yean Yang, M.D.¹, Han Jo Kim, M.D.¹, Jin A Yun, M.D.¹, Hyun Jung Kim, M.D.¹, Sang Cheol Lee, M.D.¹, Sang Byung Bae, M.D.¹, Chan Kyu Kim, M.D.¹, Nam Su Lee, M.D.¹, Seong Kyu Park, M.D.^1,, Kyu Teak Lee, M.D.¹, Jong Ho Won, M.D.¹, Dae Sik Hong, M.D.¹, Hee Sook Park, M.D.¹, Hee Kyung Kim, M.D.²

¹Department of Internal Medicine, University of Soonchunhyang Collage of Medicine, Bucheon, Korea

²Department of Pathology, University of Soonchunhyang Collage of Medicine, Bucheon, Korea

Correspondence to：Seong Kyu Park, M.D. Department of Internal Medicine, Division of Hematology & Oncology, Soonchunhyang University Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon 420-853, Korea Tel: ＋82-32-621-5185, Fax: ＋82-32-621-5018 E-mail: skpark@schbc.ac.kr

Received 31 July 2009 Revised 1 December 2009 Accepted 4 December 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Extranodal NK-T cell lymphoma is a subtype of non-Hodgkin's lymphoma (NHL) and this most commonly affects the nasal and paranasal cavities. Primary lymphoma of the gallbladder is extremely rare and solitary relapsed extranodal NK-T cell lymphoma of the gallbladder has not yet been reported in Korea. We experienced a case of a solitary relapsed extranodal NK-T cell lymphoma of the gallbladder. One year earlier, a 55-year-old man was diagnosed with extranodal NK-T cell lymphoma of the anus, and he underwent six cycles of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine and prednisone), and he achieved complete remission. The patient was admitted for right upper quadrant pain. Computed tomography (CT) performed on readmission revealed gallbladder wall thickening. Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed hypermetabolic lesions along the gallbladder wall. The specimen obtained at cholecystectomy revealed CD3(+) and CD56(+) lymphoma, which is characteristic of NK-T cell lymphoma.

Keywords: Extranodal NK-T cell lymphoma, Gallbladder cancer, Non-Hodgkin's lymphoma

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Fig. 1.

Dynamic abdomen-pelvic CT scans showed that the mucosal surface of gallbladder was irregularly thickened and its lamina layer was also enhanced.

Fig. 2.

Focal hypermetabolism was observed in the upper and mid-body portion of the gallbladder on FDG-PET scan (p-SUV=9.7).

Fig. 3.

Pathologic findings of gallbladder (A) The gallbladder was thickened diffusely and showed granular appearance. (B) An artery was infiltrated with lymphoma and destructed (H-E, ×100). And the lymphoma cells were stained strongly for (C) CD3 and (D) CD56 (Immunohistochemistry, ×200).

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