A Case of Multicentric Castleman's Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination

Sang Hyuk Park; Chan-Jeoung Park; Jooryung Huh; Seongsoo Jang; Hyun-Sook Chi; Cheolwon Suh

doi:10.5045/kjh.2009.44.3.172

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Park, Park, Huh, Jang, Chi, and Suh: A Case of Multicentric Castleman's Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination

Case Report

Korean J Hematol 2009;44(3):172-176.

Published online: 20 September 2009

DOI: https://doi.org/10.5045/kjh.2009.44.3.172

A Case of Multicentric Castleman's Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination

Sang Hyuk Park, M.D.¹, Chan-Jeoung Park, M.D.^1,, Jooryung Huh, M.D.², Seongsoo Jang, M.D.¹, Hyun-Sook Chi, M.D.¹, Cheolwon Suh, M.D.³

¹Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea

²Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea

³Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea

Correspondence to：Chan-Jeoung Park, M.D. Departments of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine 388-1, Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea Tel: ＋82-2-3010-4508, Fax: ＋82-2-478-0884 E-mail: cjpark@amc.seoul.kr

Received 14 April 2009 Revised 29 July 2009 Accepted 29 July 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Castleman's disease (CD) is an uncommon lymphoproliferative disorder presenting with a variable spectrum of clinical manifestations. CD is classified into two subtypes, Localized CD and Multicentric CD, by clinical manifestation, and is divided into 2 histopathologic types: a hyaline-vascular type (HV) or a plasma-cell type (PC). Multicentric CD show PC type predominantly and show systemic symptoms, such as fever, night sweat, malaise, ascites, edema, and more than half show multiple lymphadenopathy and hepatosplenomegaly. We report a case of 67 year old man with multicentric CD presented with fever of unknown origin and diagnosed with lymph node biopsy and bone marrow examination with a brief review of the literature.

Keywords: Multicentric Castleman's disease, Lymph node biopsy, Bone marrow examination

References

1. Jongsma TE, Verburg RJ, Geelhoed-Duijvestijn PH. Castleman's disease: a rare lymphoproliferative disorder. Eur J Intern Med. 2007; 18:87–9.

2. Kim EA, Lee CG, Kim HS. Two cases of Castleman's disease in children. J Korean Pediatric Soc. 2003; 46:203–6.

3. Herrada J, Cabanillas FF. Multicentric Castleman's disease. Am J Clin Oncol. 1995; 18:180–3.

4. Maslovsky I, Uriev L, Lugassy G. The heterogeneity of Castleman disease: report of five cases and review of the literature. Am J Med Sci. 2000; 320:292–5.

5. Shahidi H, Myers JL, Kvale PA. Castleman's disease. Mayo Clin Proc. 1995; 70:969–77.

6. McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology. 1998; 209:221–8.

7. Frizzera G. Atypical lymphoproliferative disorders. Neoplastic Hematopathology. Williams & Wilkins. 2006. 569–622.

8. Du MQ, Liu H, Diss TC, et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood. 2001; 97:2130–6.

9. Dupin N, Diss TL, Kellam P, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 2000; 95:1406–12.

10. Parravicini C, Corbellino M, Paulli M, et al. Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease. Am J Pathol. 1997; 151:1517–22.

11. Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood. 1995; 86:1243–54.

12. Kim JE, Kim CJ, Park IA, et al. Clinicopathologic study of Castleman's disease in Korea. J Korean Med Sci. 2000; 15:393–8.

13. Bacon CM, Miller RF, Noursadeghi M, McNamara C, Du MQ, Dogan A. Pathology of bone marrow in human herpes virus-8 (HHV8)-associated multicentric Castleman disease. Br J Haematol. 2004; 127:585–91.

14. Kreft A, Weber A, Springer E, Hess G, Kirkpatrick CJ. Bone marrow findings in multicentric Castleman disease in HIV-negative patients. Am J Surg Pathol. 2007; 31:398–402.

Fig. 1.

A large fibronodular granulomatous lesion composed of small lymphocytes, spindle cells, histiocytes and plasma cells (A and B) and megakaryocytic hyperplasia with frequent cluster formation (C) on bone marrow biopsy (H&E stain, (A) ×200, (B) ×400, (C) ×400).

Fig. 2.

Interstitial polyclonal plasma cell hyperplasia with CD138 positivity and lambda light chain predominance (Immunohistochemistry, ×400, A) CD138, (B) kappa light chain, (C) lambda light chain.

Fig. 3.

An angiomyoproliferative lesion on lymph node biopsy (H&E stain, ×200).

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