Journal List > Korean J Hematol > v.44(2) > 1032814

Korean J Hematol. 2009 Jun;44(2):104-107. Korean.
Published online June 30, 2009.
Copyright © 2009 Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
Primary Diffuse Large B Cell Lymphoma of the Bladder
Seon Kyeong Kim, M.D., Mi Hyun Kim, M.D., Naria Lee, M.D., Donghyuk Cha, M.D., Hyojeong Kim, M.D., Young Jin Choi, M.D., Joo Seop Chung, M.D. and Goon Jae Cho, M.D.
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.

Correspondence to: Young Jin Choi, M.D. Department of Internal Medicine, Pusan National University School of Medicine, 10, Ami-dong 1ga, Seo-gu, Busan 602-739, Korea. Tel: +82-51-240-7225, Fax: +82-51-254-3127, Email:
Received March 09, 2009; Revised June 19, 2009; Accepted June 22, 2009.


Primary malignant lymphoma of the urinary bladder is a rare disease, and it accounts for only 0.2% of all the cases of extranodal lymphoma. The prognosis of primary bladder lymphoma has been favorable, with many patients being alive and well several years after treatment. We report here on a case of primary diffuse large B cell lymphoma of the urinary bladder in a 75-year-old man patient who presented with a one-month history of persistent dysuria. The abdominal CT revealed a mass at the posterior wall of the urinary bladder. The tissue obtained by transurethral cystoscopy showed an atypical lymphoid proliferation, which was consistent with diffuse large B cell lymphoma. The patient received systemic chemotherapy of rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and he achieved a significant partial remission.

Keywords: Urinary bladder; Primary; Diffuse large B cell lymphoma


Fig. 1
Abdominal CT scan finding. (A) Marked wall thickening of bladder wall and soft tissue mass around both distal ureter. (B) Significant interval decrease in the size of lobulated mass in bladder and bladder wall thickening.
Click for larger image

Fig. 2
Microscopic findings of mass at posterior wall of urinary bladder. (A) Atypical lymphoid proliferations consistent with diffuse large B cell lymphoma (H&E stain, ×400). (B) Immunohistochemically, tumor cells show strong positivity for the B-cell marker (L26 stain, ×400). (C) Immunohistochemically, tumor cells show strong positivity for the leukocyte common antigen (LCA) (LCA stain, ×400).
Click for larger image

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