Primary Diffuse Large B Cell Lymphoma of the Bladder

Seon Kyeong Kim; Mi Hyun Kim; Naria Lee; Donghyuk Cha; Hyojeong Kim; Young Jin Choi; Joo Seop Chung; Goon Jae Cho

doi:10.5045/kjh.2009.44.2.104

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Kim, Kim, Lee, Cha, Kim, Choi, Chung, and Cho: Primary Diffuse Large B Cell Lymphoma of the Bladder

Case Report

Korean J Hematol 2009;44(2):104-107.

Published online: 20 June 2009

DOI: https://doi.org/10.5045/kjh.2009.44.2.104

Primary Diffuse Large B Cell Lymphoma of the Bladder

Seon Kyeong Kim, M.D., Mi Hyun Kim, M.D., Naria Lee, M.D., Donghyuk Cha, M.D., Hyojeong Kim, M.D., Young Jin Choi, M.D., Joo Seop Chung, M.D., Goon Jae Cho, M.D.

Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea

Correspondence to：Young Jin Choi, M.D. Department of Internal Medicine, Pusan National University School of Medicine 10, Ami-dong 1ga, Seo-gu, Busan 602-739, Korea Tel: ＋82-51-240-7225, Fax: ＋82-51-254-3127 E-mail: porori701@hanmail.net

Received 9 March 2009 Revised 19 June 2009 Accepted 22 June 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary malignant lymphoma of the urinary bladder is a rare disease, and it accounts for only 0.2% of all the cases of extranodal lymphoma. The prognosis of primary bladder lymphoma has been favorable, with many patients being alive and well several years after treatment. We report here on a case of primary diffuse large B cell lymphoma of the urinary bladder in a 75-year-old man patient who presented with a one-month history of persistent dysuria. The abdominal CT revealed a mass at the posterior wall of the urinary bladder. The tissue obtained by transurethral cystoscopy showed an atypical lymphoid proliferation, which was consistent with diffuse large B cell lymphoma. The patient received systemic chemotherapy of rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and he achieved a significant partial remission.

Keywords: Urinary bladder, Primary, Diffuse large B cell lymphoma

References

1. Bang SM, Hahn JS, Lee JE, Kim GE, Yang WI. Primary lymphoma of genitourinary tract. Korean J Med. 2003; 64:567–75.

2. Robert N, Jacques F, Valerie B, Susan S. The epidemiology of non-hodgkin's lymphoma: comparison of nodal and extranodal sites. Int J Cancer. 1997; 72:923–30.

3. Hahn JS, Ko YW, Min YH, et al. Statistical analysis of malignant lymphoma in Korea. Korean J Hematol. 1995; 30:197–214.

4. Freeman C, Berg JW, Cutler SJ. Occurence and prognosis of extranodal lymphomas. Cancer. 1972; 29:252–60.

5. Ryan G, Martinelli G, Kuper M, et al. Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the international extranodal lymphoma study group. Ann Oncol. 2008; 19:233–41.

6. Zucca E, Rogero E, Bertoni F, Cavalli F. Primary extranodal non-Hodgkin's lymphomas. Part 1: gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol. 1997; 8:727–37.

7. Lee JY, Kim WS, Song SY, et al. A case of MALT lymphoma of the urinary bladder. Korean J Med. 2002; 63:98–102.

8. Masahiko O, Katsuyuki A, Keisuke H, Akihisa K. Malignant lymphoma of bladder. Cancer. 1993; 72:1969–74.

9. Hughes M, Morrison A, Jackson R. Primary bladder lymphoma: management and outcome of 12 patients with a review of the literature. Leuk Lymphoma. 2005; 46:873–7.

Fig. 1.

Abdominal CT scan finding. (A) Marked wall thickening of bladder wall and soft tissue mass around both distal ureter. (B) Significant interval decrease in the size of lobulated mass in bladder and bladder wall thickening.

Fig. 2.

Microscopic findings of mass at posterior wall of urinary bladder. (A) Atypical lymphoid proliferations consistent with diffuse large B cell lymphoma (H&E stain, ×400). (B) Immunohistochemically, tumor cells show strong positivity for the B-cell marker (L26 stain, ×400). (C) Immunohistochemically, tumor cells show strong positivity for the leukocyte common antigen (LCA) (LCA stain, ×400).

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