A Case of Granulocytic Sarcoma in the Brain of a Patient with Acute Erythroleukemia

Jae-Hoon Cheong; Bo-ran Kwon; Mi-ra Kim; Mu-gon Song; Young-mi Seol; Young-Jin Choi; Ho-Jin Shin; Joo-Seop Chung; Goon-Jae Cho

doi:10.5045/kjh.2008.43.4.272

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Cheong, Kwon, Kim, Song, Seol, Choi, Shin, Chung, and Cho: A Case of Granulocytic Sarcoma in the Brain of a Patient with Acute Erythroleukemia

Case Report

Korean J Hematol 2008;43(4):272-275.

Published online: 19 January 2008

DOI: https://doi.org/10.5045/kjh.2008.43.4.272

A Case of Granulocytic Sarcoma in the Brain of a Patient with Acute Erythroleukemia

Jae-Hoon Cheong, M.D., Bo-ran Kwon, M.D., Mi-ra Kim, M.D., Mu-gon Song, M.D., Young-mi Seol, M.D., Young-Jin Choi, M.D., Ho-Jin Shin, M.D., Joo-Seop Chung, M.D., Goon-Jae Cho, M.D.

Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea

Correspondence to：Goon-Jae Cho, M.D. Department of Internal Medicine College of Medicine Pusan National University 1-10, Ami-dong, Seo-gu, Busan 602-739, Korea Tel:+82-51-240-7225Fax:+82-51-254-3127 E-mail:gicho@pusan.ac.kr

Received 8 May 2008 Revised 20 November 2008 Accepted 24 November 2008

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Granulocytic sarcoma is a localized tumor that's composed of immature granulocytic cells and this is more common in patient with 8;21 translocation. We present here a case in a 64-year-old man who was diagnosed with acute myelogenous leukemia (erythroleukemia) that had a complex hyperdiploid karyotype. While he underwent chemotherapy, he developed nausea, vomiting, headache and dysarthria. After several diagnostic work-ups, granulocytic sarcoma in the cerebellum and leptomeningeal metastasis of his leukemia were found on the magnetic resonance imaging and the cerebrospinal fluid cytology.

Keywords: Leukemia, Erythroblastic, Acute, Sarcoma, Myeloid, Brain

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Fig. 1

The touch preparation of bone marrow biopsy demonstrating moderately hypercellular marrow with marked proliferation of severe dysplastic erythroid precursors (80% of all nucleated cells) and blasts. (Wright-Giemsa stain, 1,000×, adapted from Department of Laboratory Medicine, Pusan National University Hospital).

Fig. 2

Dysplastic erythroid precursors are Periodic Acid Schiff (PAS) stain positive. (1,000×, adapted from Department of Laboratory Medicine, Pusan National University Hospital).

Fig. 3

Magnetic resonance imaging shows mass lesion in left cerebellum which shows high signal intensity on T1-weighted image and low signal intensity on T2-weighted image.

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