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Abstract
Deferasirox is a once-daily, oral iron-chelating agent that is now widely available for the treatment of transfusional hemosiderosis. Deferasirox represents a significant advance in the treatment of iron overload, as the availability of an effective oral therapy has the potential to relieve many patients from the burden of frequent parenteral therapy with the previous reference standard iron chelator, deferoxamine. The well-known drug-related adverse events associated with deferasirox include gastrointestinal disturbances, rash, elevations in liver enzyme levels, and mild increases in serum creatinine levels, but acute renal failure is not common. The authors report a case of acute tubulointerstitial nephritis induced by deferasirox following hematopoietic stem cell transplantation for severe aplastic anemia.
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Fig. 1
Liver MRI shows transfusional hemosiderosis or hemochromatosis involving the liver, spleen, and probably bone marrow.
Fig. 2
Gallium scan of kidney. The uptake intensity in the kidneys is increased up to 48hr post-injection. Furthermore renal activity is more prominent on the images obtained on 72 hr post-injection, suggesting active inflammation of the kidneys.
Table 1.
Comparison of renal function tests in pre- & post-deferasirox treatment
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