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Abstract
Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL.
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Fig. 1
Angioimmunoblastic T cell lymphoma in the cervical lymph node. (A) The nodal architecture was effaced by a diffuse infiltration of medium-sized atypical lymphocytes with clear cytoplasm in a background of arborizing endothelial venules and various-sized admixture (H&E, ×400). (B) Tumor cells were positive for CD3. (C) Tumor cells were positive for CD21.
Fig. 2
The tonsilar biopsy showed a diffuse large B cell lymphoma that developed 13 months after the diagnosis of angioimmunoblastic T cell lymphoma. (A) Diffuse infiltration of large-sized lymphoid cells were shown (H&E, ×400). (B) Tumor cells were diffusely positive for CD20. (C) In situ hybridization of EBV showed the positivity of a few large lymphocytes.
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